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Guest Editor: Kwok-yung Yuen (Department of Microbiology, The University of Hong Kong, Hong Kong, China)

Zika, which was first isolated from the serum of a febrile sentinel rhesus macaque in 1947 in Zika Forest of Uganda, is emerging as a major ongoing pandemic worldwide in the last few years. Zika virus is a single-stranded ribonucleic acid (RNA) virus mainly transmitted by mosquitoes. EMI has published a growing list of novel research reports related to different aspects of Zika epidemics and a special topic in this area is established to facilitate the easy access by global researchers.

Emerging Microbes & Infections

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Title Author Article Type
Zika structural genes determine the virulence of African and Asian lineages B. T. D. Nunes, C. R. Fontes-Garfias, C. Shan et al Original Article
A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice D. B. Kum, R. Boudewijns, J. Ma et al Original Article
Longitudinal analysis of the antibody repertoire of a Zika virus-infected patient revealed dynamic changes in antibody response X. Niu, Q. Yan, Z. Yao et al Original Article
Increased temperatures reduce the vectorial capacity of Aedes mosquitoes for Zika virus M. G. Onyango, S. M. Bialosuknia, A. F. Payne et al Original Article


Title Author Article Type
Zika virus threshold determines transmission by European Aedes albopictus mosquitoes M. Vazeille, Y. Madec, L. Mousson et al Original Article
Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity N. D. Collins, S. G. Widen, L. Li et al Original Article
The African strain of Zika virus causes more severe in utero infection than Asian strain in a porcine fetal transmission model D. Udenze, I. Trus, N. Berube et al Original Article
Zika virus differentially infects human neural progenitor cells according to their state of differentiation and dysregulates neurogenesis through the Notch pathway P. Ferraris, M. Cochet, R. Hamel et al Original Article
Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model X. Niu, L. Zhao, L. Qu et al Original Article
Transmission potential of African, Asian and American Zika virus strains by Aedes aegypti and Culex quinquefasciatus from Guadeloupe (French West Indies) L. Hery, A. Boullis, C. Delannay & A. Vega-Rúa Original Article
Genetic and biochemical characterizations of Zika virus NS2A protein X. Zhang, X. Xie, J. Zou et al Original Article
Cell surface α2,3-linked sialic acid facilitates Zika virus internalization C. W. Tan, C. H. H. Hor, S. S. Kwek et al Original Article
Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons W. Zhou, M. Woodson, M. B. Sherman et al Original Article
Naturally infected Aedes aegypti collected during a Zika virus outbreak have viral titres consistent with transmission S. R. Azar, E. E. Diaz-Gonzalez, R. Danis-Lonzano et al Letter
Infectivity of Zika virus on primary cells support tree shrew as animal model L. Zhang, Z. L. Shen, Y. Feng et al Original Article
Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells S. Pujhari, M. Brustolin, V. M. Macias et al Original Article


Title Author Article Type
Zika virus infection in human placental tissue explants is enhanced in the presence of dengue virus antibodies in-vitro K. Hermanns, C. Göhner, A. Kopp et al Original Article
Experimental transmission of Zika virus by Aedes japonicus japonicus from southwestern Germany S. Jansen, A. Heitmann, R. Lühken et al Original Article
Restriction of Zika virus infection and transmission in Aedes aegypti mediated by an insect-specific flavivirus H. Romo, J. L. Kenney, B. J. Blitvich & A. C. Brault Original Article
Zika virus shedding in the stool and infection through the anorectal mucosa in mice C. Li, Y. Q. Deng, S. Zu et al Original Article
Live Zika virus chimeric vaccine candidate based on a yellow fever 17-D attenuated backbone F. Touret, M. Gilles, R. Klitting et al Original Article
Differential transmission of Asian and African Zika virus lineages by Aedes aegypti from New Caledonia E. Calvez, O. O’Connor, M. Pol et al Original Article
Long-term clinical outcomes of Zika-associated Guillain-Barré syndrome A. Y. Chang, R. Lynch, K. Martins et al Correspondence
Zika convalescent macaques display delayed induction of anamnestic cross-neutralizing antibody responses after dengue infection W. G. Valiant, Y. J. S. Huang, D. L. Vanlandingham et al Original Article
ZIKA virus infection causes persistent chorioretinal lesions M. Manangeeswaran, J. L. Kielczewski, H. N. Sen et al Original Article
Human testicular organoid system as a novel tool to study Zika virus pathogenesis D. P. Strange, N. P. Zarandi, G. Trivedi et al Correspondence
Re-visiting the evolution, dispersal and epidemiology of Zika virus in Asia J. H.-O. Pettersson, J. Bohlin, M.Dupont-Rouzeyrol et al Original Article
Neurotropism and behavioral changes associated with Zika infection in the vector Aedes aegypti J. Gaburro, A. Bhatti, J. Harper et al Original Article
A novel sheet-like virus particle array is a hallmark of Zika virus infection J. Liu, B. A. Kline, T. A. Kenny et al Original Article
Microencephaly in fetal piglets following in utero inoculation of Zika virus P. J. Wichgers Schreur, L. van Keulen, D. Anjema, J. Kant & J. Kortekaas Original Article
A single residue in the αB helix of the E protein is critical for Zika virus thermostability D. Y. Xie, Z. Y. Liu, Q. G. Nian et al Correspondence
Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses W. Tai, L. He, Y. Wang et al Original Article


Title Author Article Type
Zika virus evolution on the edges of the Pacific Ocean M. Dupont-Rouzeyrol, L. Diancourt, E. Calvez et al Letter
Lack of evidence for Zika virus transmission by Culex mosquitoes C. M. Roundy, S. R. Azar, A. C. Brault et al Letter
Response to: ‘Lack of evidence for Zika virus transmission by Culex mosquitoes’ C. Ayres, D. Guedes, M. Paiva et al Letter
Specific detection of dengue and Zika virus antibodies using envelope proteins with mutations in the conserved fusion loop A. Rockstroh, B. Moges, L. Barzon et al Original Article
Could Zika virus emerge in Mainland China? Virus isolation from nature in Culex quinquefasciatus, 2016 S. Song, Y. Li, S. Fu et al Letter
Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III Y. Wu, S. Li, L. Du et al Original Article
Zika virus infection confers protection against West Nile virus challenge in mice Á. Vázquez-Calvo, A. -B. Blázquez, E. Escribano-Romero et al Original Article
Zika virus infects renal proximal tubular epithelial cells with prolonged persistency and cytopathic effects J. Chen, Y. -F. Yang, J. Chen Original Article
Disease reservoirs: from conceptual frameworks to applicable criteria L. K. Hallmaier-Wacker, V. J. Munster & S. Knauf Review
Dengue burden in India: recent trends and importance of climatic parameters S. R. Mutheneni, A. P. Morse, C. Caminade & S. M. Upadhyayula Original Article
Zika virus replication in the mosquito Culex quinquefasciatus in Brazil D. R. D Guedes, M. H. S. Paiva, M. M. A. Donato et al Original Article
Humoral cross-reactivity between Zika and dengue viruses: implications for protection and pathology L. Priyamvada, W. Hudson, R. Ahmed & J. Wrammert Review
AXL is not essential for Zika virus infection in the mouse brain F. Li, P. R. Wang, L. B. Qu et al Letter
Zika virus infection reprograms global transcription of host cells to allow sustained infection S. K. Tiwari, J. Dang, Y. Qin et al Original Article


Title Author Article Type
Zika virus genome biology and molecular pathogenesis A. Wang, S. Thurmond, L. Islas, K. Hui & R. Hai Review
The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages J. Liu, Y. Sun, W. Shi et al Original Article
Neonatal pigs are susceptible to experimental Zika virus infection J. Darbellay, K. Lai, S. Babiuk et al Letter
From discovery to outbreak: the genetic evolution of the emerging Zika virus H. Liu, L. Shen, X. L. Zhang et al Letter
Evolution of codon usage in Zika virus genomes is host and vector specific A. M. Butt, I. Nasrullah, R. Qamar & Y. Tong Original Article
Culex pipiens quinquefasciatus: a potential vector to transmit Zika virus X. X. Guo, C. X. Li, Y. Q. Deng et al Original Article
Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs J. F. W. Chan, C. C. Y. Yip, J. O. L. Tsang et al Original Article
Epidemiologic investigation of a family cluster of imported ZIKV cases in Guangdong, China: probable human-to-human transmission Y. Yin, Y. Xu, L. Su et al Original Article
Zika virus-associated brain damage: animal models and open issues G. Di Guardo, P. B. B. Braga & J. P. S. Peron Original Article
Increasing genetic diversity of Zika virus in the Latin American outbreak W. Shi, Z. Zhang, C. Ling et al Letter
Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic Z. Zhu, J. F. W. Chan, K. M. Tee et al Original Article
Zika virus outbreak: ‘a perfect storm’ J. W. Ai, Y. Zhang & W. Zhang News & Views
Aedes mosquitoes and Zika virus infection: an A to Z of emergence? C. R. Howard Commentary