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Hepatitis- updates from the classical emerging infections

Guest Editor: Zhenghong Yuan (Fudan University, China)

Hepatitis viruses (HAV, HBV, HCV, HDV, HEV) belong to diverse virus families and are transmitted by different routes. Some are enveloped and the genome can be single-stranded RNA or double-stranded DNA. Though HAV and HEV usually cause acute infections, chronic HEV infections have been observed recently. Various mechanisms for persistent infections by HBV or HCV, and their roles leading to liver cirrhosis and hepatocellular carcinoma have been further explored. Novel data on the molecular biology of hepatitis viruses, antiviral drugs, and new therapeutic targets have been presented regularly. EMI Special Topic - Viral Hepatitis will cover these hepatitis viruses in terms of biology, pathogenesis, immune response, therapy, and prevention, with special emphasis on recent progress.

Emerging Microbes & Infections

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Title Author Article Type
Life cycle and morphogenesis of the hepatitis E virus K. Himmelsbach, D. Bender & E. Hildt Review
Identification and genetic characterization of a novel parvovirus associated with serum hepatitis in horses in China G. Lu, L. Sun, J. Ou et al Original Article
Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection L. Yuan, X. Liu, L. Zhang et al Original Article
Sequence analysis of integrated hepatitis B virus DNA during HBeAg-seroconversion M. A. Budzinska, N. A. Shackel, S. Urban & T. Tu Original Article
Adaptive mutation F772S-enhanced p7-NS4A cooperation facilitates the assembly and release of hepatitis C virus and is associated with lipid droplet enlargement X. Duan, M. I. Anwar, Z. Xu et al Original Article
Bona fide receptor for hepatitis B and D viral infections: Mechanism, research models and molecular drug targets Y. Yu, S. Li & W. Liang Review
Continuous decline of hepatitis E virus seroprevalence in southern Germany despite increasing notifications, 2003–2015 H. Mahrt, M. Schemmerer, G. Behrens et al Original Article
A “sandwich” strategy for functional cure of chronic hepatitis B X. Y. Wang & Y. M. Wen Correspondence
RBM24 stabilizes hepatitis B virus pregenomic RNA but inhibits core protein translation by targeting the terminal redundancy sequence Y. Yao, B. Yang, H. Cao et al Original Article
Avian hepatitis E virus infection of duck, goose, and rabbit in northwest China B. Liu, M. Fan, B. Zhang et al Correspondence
Author Correction: Prevalence and characteristics of hypoxic hepatitis in the largest single-centre cohort of avian influenza A(H7N9) virus-infected patients with severe liver impairment in the intensive care unit Y. M. Zhang, J. M. Liu, L. Yu et al Author Correction
Origin and dispersal of Hepatitis E virus D. Forni, R. Cagliani, M. Clerici & M. Sironi Original Article





Title Author Article Type
Progress towards a hepatitis C virus vaccine L. M. J. Law, A. Landi, W. C. Magee et al Review
Hepatitis B virus reverse transcriptase: diverse functions as classical and emerging targets for antiviral intervention S. A. Jones & J. Hu Review
T-cell responses in hepatitis B and C virus infection: similarities and differences J. Schmidt, H. E. Blum & R. Thimme Review
Pathobiology of hepatitis E: lessons learned from primate models R. H. Purcell, R. E. Engle, S. Govindarajan et al Original Article
Hepatitis B virus genetic variants: biological properties and clinical implications S. Tong, J. Li, J. R. Wands & Y. M. Wen Review