Evidence-Based Toxicology

Responsible use of AI in toxicology

There is an increasing need for high-quality, authoritative guidance on the responsible use of AI in research. A recent response to this need is the RAISE recommendations for responsible use of AI in evidence synthesis (Thomas et al. 2026).

RAISE is developing into an important series of guidance documents for the responsible use of artificial intelligence in systematic review and evidence mapping projects.

However, we note that many of the RAISE recommendations apply equally well to primary research as they do evidence synthesis, apply not only to AI but any computational approach to analysing and using toxicology data, and RAISE needs adapting for the unique context of toxicology research.

To encourage engagement with RAISE specifically, and the issues of responsible use of AI and computational methods in toxicology more generally, we are inviting submissions on the implications of RAISE for toxicology.

Two members of the Evidence-Based Toxicology Editorial Board are co-authors of RAISE and we welcome discussion of submission ideas with prospective authors.

Suggested themes for submitted articles

We are inviting research articles (primary studies, evidence syntheses) and reflective pieces (comment articles) of any length (full manuscripts or research letters) about the responsible use of AI and computational methods in toxicology research.

Topics for submissions could include the following:

• Building on the research ecosystem “roles” that structure RAISE, where, how, and for whom should the RAISE recommendations be adapted for the unique scientific and cultural contexts of toxicology research?
• How should toxicologists analyse and report the performance of AI and computational tools in toxicology? This could also potentially focus on the unique needs and contributions that each research ecosystem role could have or make.
• How should toxicologists identify, select, apply, and report the use of AI and computational tools in toxicology? There is a growing plethora of tools, so identfying appropriate tools, evaluating them efficiently, and reporting their use in a way that is transparent and supportive of the development of such tools by other researchers is of particular interest.

The above are suggestions. Any interesting paper that develops or applies any theme within RAISE, either in primary or secondary research that is in or is applicable to toxicology or environmental health, is eligible for this Call for Papers.