Submit a Manuscript to the Journal
Journal of Histotechnology
For a Special Issue on
Non-Animal Tissue-Based Assays, In Vitro Cellular and Organoid Models in Culture Advancement and Histotechnology
Manuscript deadline
Special Issue Editor(s)
Chongbei Zhao,
Stowers Institute for Medical Research
[email protected]
Elizabeth A. Chlipala,
Premier Laboratory, LLC
[email protected]
Non-Animal Tissue-Based Assays, In Vitro Cellular and Organoid Models in Culture Advancement and Histotechnology
The Journal of Histotechnology invites submissions for a special issue dedicated to the expanding field of non-animal tissue-based assays, including organoids, spheroids, organ-on-chip systems, and other 3D and microphysiological models. As demand increases for human-relevant, ethically responsible alternatives to animal models, histotechnology professionals are at the forefront of enabling the validation, visualization, and interpretation of these complex systems. This issue also will focus on the transformation of in vitro cellular models towards human relevance, such as primary cell culture, induced pluripotent stem cells (iPSCs) and organoids as well as integrating these technologies with additional downstream testing such as genomics, transcriptomics, proteomics and metabolomics.
Submission Instructions
We are seeking original research articles, technical notes, case studies, commentaries, protocols and reviews that (1) address the unique histological challenges and innovations related to the processing, staining, imaging, and analysis of these advanced tissue models; (2) address the cellular model advancements and pitfalls.
Topics may include, but are not limited to:
- Histological processing and fixation strategies for organoids and 3D constructs
- Novel in vitro cellular models: Organoids, assembloids, Â spheriods, organ-on-chip
- Human iPSC derived 2D and/or 3D systems
- Novel derivation or engineering of primary or human cell lines
- Omics-based characterization, validation, and quality control frameworks
- Standardization of cellular models: protocols and open-source resources
- Integration of AI, Automation, and high-throughput screening in cell-based systems
- Special stains and immunohistochemistry adapted for in vitro tissues
- Quality assurance and validation of assay reproducibility
- Comparative studies between in vitro and in vivo tissue models
- Applications in toxicology, drug development, disease modeling, and regenerative medicine
- Emerging technologies and workflow adaptations in histopathology labs
This special issue aims to spotlight the critical contributions of histotechnology and in vitro cellular models in driving innovation and reliability in next-generation tissue models. We encourage submissions from academic, clinical, industry, and regulatory settings.