Radical-driven peroxidation of lipids in biological systems and membranes has a major effect on the functioning of the cell. Oxidative modification of lipids and its biological consequences can be a driver of disease and thus become a therapeutic target. However, these processes can only be rationally targeted if the chemical mechanisms underlying lipid peroxidation are well understood. Likewise, it is key to understand how the cellular environment shapes the process and outcome of lipid peroxidation. And finally, it is necessary to understand the mechanisms by which lipid peroxidation products affect their cellular targets. This special issue is intended to highlight the state of the art in the chemistry and biology of lipid peroxidation and to explore innovative strategies that may lead to novel therapeutic approaches.
We are inviting contributions (research articles and reviews) that focus on:
- Chemistry of lipid peroxidation
- Identification of novel products derived from lipid peroxidation
- Analysis of mechanisms involved in the lipid peroxidation process
- Novel mechanisms in anti-oxidation chemistry
- Modern analytical approaches to quantify lipid peroxidation and its products
- Radical-mediated oxidation of biological targets other than lipids
- Ferroptosis with a focus on the role of lipid hydroperoxides
- Role of lipid peroxidation products as drivers of disease
- Analysis of lipid peroxidation products in biological systems
- Signalling of lipid peroxidation products in homeostasis and disease
