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Submit a Manuscript to the Journal
Inhalation Toxicology

For a Special Issue on
Contribution of specific lipids and lysosomal membrane properties to LMP, autophagy and inflammation

Manuscript deadline
30 November 2022

Cover image - Inhalation Toxicology

Special Issue Editor(s)

Andrij Holian, Ph.D., Center for Environmental Health Sciences, University of Montana, Missoula, MT, USA
[email protected]

Mary Gulumian, Ph.D., School of Pathology, University of the Witwatersrand, North West University, Potchefstroom, South Africa
[email protected]

Submit an ArticleVisit JournalArticles

Contribution of specific lipids and lysosomal membrane properties to LMP, autophagy and inflammation

Inhaled particles are recognized by the innate monitoring system, alveolar macrophages, and taken up for degradation and/or removal from the lung. Certain exogenous particles (e.g., crystalline silica, asbestos, some engineered nanomaterials) that are proinflammatory do so by initiating a series of events within the phagolysosome leading to lysosomal membrane permeability as the key initiating event resulting in leakage of lysosomal degradative enzymes. Lysosomal contents such as cathepsin B and other proteases initiate NLRP3 assembly leading to production and release of IL-1beta and IL-18 leading to lung inflammation as well as damage to mitochondria and other organelles initiating oxidative stress, cell injury and altered autophagy. While these events have been described for some time, the critical roles of lysosomal lipid metabolism and cholesterol metabolism/cycling to regulate lysosomal membrane integrity are less understood. The purpose of this special issue is to assemble original research, critical reviews, and white papers that will provide needed new information to better describe events and tools to measure events at the particle/membrane interface in order to develop potential novel therapeutics.

Submission Instructions

Please select special issue title "Contribution of specific lipids and lysosomal membrane properties to LMP, autophagy and inflammation" when submitting your paper to ScholarOne.

For this special issue we encourage original research, critical reviews, and white papers.

Accepted manuscripts will be published online after acceptance. The assembled final printed special issue will contain all manuscripts and will be published shortly after all manuscripts for the special issue are complete.

Instructions for AuthorsSubmit an Article

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