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On behalf of the Global HIV and Pain Task Force, AIDS Care is issuing a call for manuscripts to be published as part of a special issue on the topic of chronic pain in people living with HIV. This may include etiological factors, pathophysiology, epidemiology, psychosocial aspects, management approaches, or other relevant topics including opioid/substance use at the editors' discretion. We ask that prospective authors first submit a letter of interest (LOI) to publish in this special issue whereby they describe the proposed topic of their manuscript and key findings. We envision that the LOI will essentially be the abstract for the proposed manuscript. A title page with authors and affiliations should also be included.