Acta Clinica Belgica

Endocrine, Immune and Metabolic Functions of Vitamin D: Implications for Diagnostics and Therapy

Vitamin D has long been recognized for its role in calcium homeostasis and skeletal health, but in recent years, it has emerged as a central player in a wide array of physiological systems. This special issue invites cutting-edge research and reviews that explore the diverse and complex roles of vitamin D — from molecular and cellular mechanisms to clinical applications and public health strategies.

We welcome contributions that span the full spectrum of vitamin D science, including but not limited to:

• Novel insights into vitamin D metabolism, receptor biology, and signaling pathways

• The role of vitamin D in immune regulation, cancer biology, cardiometabolic health, and neuroendocrinology

• Biomarkers of vitamin D status and their integration into diagnostic and prognostic models

• The impact of vitamin D deficiency and supplementation across different populations and life stages

• Laboratory innovations in vitamin D measurement, bioavailability, and genetic variability

• Clinical trials assessing vitamin D as a preventive or therapeutic agent in chronic disease

• Global and population-level perspectives on vitamin D policy, fortification, and accessibility