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31 December 2021
Organoids: From Development to Pathophysiology
Organoids are in vitro 3D cellular structures, made of multiple cell types, that are grown in an organized manner and reproducing at least one function of the organ they resemble. Organoids can mimic in vivo differentiation of embryonic stem cells (ESCs) or pluripotent stem cells (PSCs) into multiple cell types, recapitulating proper tissue architecture, thus, combining in vitro culture advantages and in vivo physiological conditions. This capability has provided meaningful insights in stem cell biology, organogenesis and morphogenesis in normal and pathophysiological contexts. Therefore, organoids are increasingly chosen as the model of choice to study developmental processes, disease modeling, or to screen for new molecules.
Some of the considerable advancements that organoid culture has made possible include:
- Organoids have been made to mimic diverse organs such as eye, intestine, lung, liver, pancreas, kidney or even brain. Reproducing multiple pathologies using these organoids has been proven to model many diseases and allowed for drug screening. In particular, the use of recent technological advances such as Crispr/Cas9 genome editing on organoid culture shed light on the pathological consequences of genomic variations when patient-derived cells are not available.
- Embryoids and gastruloids bring better understanding of early human development and will answer fundamental questions in embryology, which cannot be studied by any existing animal model.
- While the implantation of organoids directly into patients to replace altered organs is not yet ready, research in the field of microfluidics to build a so-called "organs-on-chip" is currently expanding.
Because organoids are likely to revolutionize our understanding of basic molecular and cellular processing involved in tissue and organ development, we wish to devote a special issue in Cell Adhesion and Migration Journal to this topic. This special issue will aim to gather open-access technical papers, original research, review articles, and registered reports. The latter is an interesting new feature allowing the promotion of on-going research ahead of publication with the goal to trigger discussion on the most exciting advancements in organoid research field. This issue could be completed by an ethics review to bring researcher attention and moral consideration behind multi-organoid research and new therapies.
Organoid research is the future of regenerative and personalized medicine as it already reveals novel insights in various diseases and drug testing. There is no doubt that organoid studies will lead to a better understanding of the development and physiology of many organs, particularly in humans.
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This special issue will aim to gather:
- Technical Papers
- Original Research
- Review Articles
- Registered Reports
- Ethics Reviews
Registered reports are unique when compared to other publishing formats as a preliminary peer review process begins prior to data collection with the submission of a design study and protocols. This first stage of peer review ensures that bias against negative results in the publication process as well as the selective reporting of results are all but eliminated, thus fostering good research and publication practices. More information on registered reports can be found at the Center for Open Science here.
Submissions for this Special Issue will be accepted on a rolling basis. Please refer to the Cell Adhesion & Migration Instructions for Authors section for more information on submitting a manuscript for this Special Issue.
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