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01 June 2021
Biological mechanisms underlying adverse mental health outcome after trauma
The presence of trauma-related disorders is associated with dysregulations in a wide range of biological processes, from the organic to the cellular and molecular level. There is increasing evidence that these processes are not only associated with the presence or maintenance of these disorders, but are also involved in the early stages of development of these disorders and underlie differential susceptibility to these disorders.
Further elucidation of the biological processes associated with the development of trauma-related disorders is important to provide further avenues for much warranted preventive interventions to ameliorate the long-term mental health consequences of trauma. Accumulating findings support that many of the biological processes of interest are dynamic and depend on the exact stage of the disorder at the time of assessment, as well as on sex and developmental period across the lifespan.
We call for studies with adequate designs and setups to address these specific research questions including prospective and longitudinal cohort studies, but also experimental, preclinical and computational studies investigating biological processes in relation to relevant cognitive or behavioral aspects of trauma-related disorders.
This special issue seeks to highlight human and animal research that advances our understanding of the biological processes and mechanisms associated with differential susceptibility, i.e. risk versus resilience, as well as the development of trauma-related disorders.
The special issue invites submissions on the following topics:
- Acute and long-term biological effects of traumatic stress
- Biological factors associated with risk and resilience to trauma-related disorders
- Biological processes of symptom onset and development after trauma
- Using biological information to forecast mental health outcome after trauma
- Mediators and moderators of biological mechanisms of trauma-related disorders
- Intervention studies targeting or assessing biological processes associated with development of trauma-related disorders.
- Impact of sex as a biological variable (SABV) on mental health outcome after trauma
- Other biological papers relevant to the field of psychotraumatology
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