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30 April 2021
Clinical Applications of Spectroscopy
Spectroscopic techniques appear promising to have immense potential in helping with the diagnosis and monitoring of human diseases including infections, inflammatory conditions and various cancers. Currently, although imaging can aid in diagnosis of a lot of disease processes, histopathological tissue diagnosis remains the gold standard for diagnosis of most clinical conditions. In this respect, spectroscopic techniques can be of immense value to aid histopathological diagnosis.
Spectroscopy with its advances in technology, is central to novel applications in bioengineering, natural sciences and now in medical field. Spectroscopic techniques can help in the diagnosis of infections at point of care. These techniques have attracted growing interest as biomedical tools for the early diagnosis and monitoring of human disease. Need to study bacteria and viruses has seen a renewed interest with recent technologies capable of providing snapshot information about the overall composition of biological species. As a result, complex biological samples such as urine, CVF, blood, saliva, breast milk, etc. can now be assessed with unparalleled efficiency and resolution using techniques such as proton nuclear magnetic resonance (1H-NMR), RS and IR.
Use of spectroscopic techniques for clinical applications is increasing rapidly, especially in the use of Infrared (IR) and Raman (RS) spectroscopy for the diagnosis of human diseases including infections, inflammatory conditions and various cancers.
Recently, clinical applications of IR and Raman spectroscopy related to malignancy, and cancer detection have increased rapidly attracting significant attention among both clinical and non-clinical researchers. These methods have been reported on several biological tissues including bone, skin, colon, lung, breast, heart, cornea, liver, prostate, gastric, larynx, oral, bladder, endometrium, multiple sclerosis and brain. These techniques can be used as robust and accurate techniques not only for the early diagnosis, but also monitoring of the disease process.
At present their use in analysis of biofluids (blood, serum, urine and saliva) is increasing with enormous pace, more and more studies are being reported in literature. Given the current challenges of COVID-19, researchers are exploring the use of these techniques for early detection of viruses (COVID-19) and studying other bacterial infections as well.
In literature, information available to clinicians and spectroscopists, including clinical, biological and biospectral chemical data and outputs of related spectral analysis is very often scattered, making it difficult for precise and accurate evaluation of chemical changes that may occur due to the progression of the disease process either for early diagnosis or monitoring through spectroscopy. Therefore, there is a need to have a special issue on Clinical Applications of Spectroscopy to have these studies reported at one place making it easier to understand the entire process for rapid and accurate analysis.
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Original research papers and reviews of high quality to address translational research in relation to medicine and spectroscopy are invited. This special issue will generate a consolidated resource for clinicians, surgeons, spectroscopists, bioengineers to develop an understanding of the early diagnosis and monitoring of the progression of disease processes.
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