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Insights from some of the Editorial team

Biofouling, The Journal of Bioadhesion and Biofilm Research

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Current research into biofilm-associated infections

Does your research concern bio-inspired antibacterial alternatives to traditional antibiotics? Our expert Editorial team, Prof. Len Evans, Prof. Carla Renata Arciola, Dr Elinor Pulcini and Dr Manuel Simões offer their insights into how biofilm research is influencing new drug-delivery technologies.

New drug-delivery technologies

In parallel with the enormous spread in the use of biomaterials in medicine the number of Biofilm-associated infections has been steadily increasing since 1990. This has resulted in devastating complications in patients wearing prostheses and assisted by medical devices, as well a huge economic burden for health systems. By 2020 in the USA alone, the projected cost of managing these infections is expected to exceed $2 billion.

Staphylococci are the most frequent etiological agent, followed by Pseudomonas aeruginosa and Enterococcus faecalis. After an initial adhesin-mediated implant colonization, the bacteria produce biofilms. The encasing of bacteria in biofilms causes serious difficulties in treating infections, since biofilm-embedded bacteria are inherently protected from antibiotic therapies.

Cutting-edge research aims to make the surfaces of implant materials not only anti-biofilm but also functionalized with other beneficial properties, such as favouring integration with host tissues, exerting anti-inflammatory activities, and promoting wound healing.

Interesting opportunities are offered by bio-inspired antibacterial substances different from traditional antibiotics. The focus should be on antimicrobial peptides and phytocompounds, especially if associated with the new technologies of drug-delivery based on nanostructured materials. Anti-infective nanomaterials and nanocoatings are currently opening up new horizons in this field of endeavor.

Prof. Len Evans, Prof. Carla Renata Arciola & Dr Elinor Pulcini

Editor's choice

The articles below have been specially selected to represent current research into the development of new drug-delivery technologies. To submit your research to Biofouling, click here.

Title Author Issue
Plasma-initiated graft polymerization as an immobilization platform for metal free Russian propolis ethanol extracts designed specifically for biomaterials Ashwin Ambi, Carolina Vera, Nisharg Parikh, et al 34(5):557-568
D-LL-31 in combination with ceftazidime synergistically enhances bactericidal activity and biofilm destruction in Burkholderia pseudomallei Saharut Wongkaewkhiaw, Suwimol Taweechaisupapong, Chitchanok Anutrakunchai, et al. 35(5):573-584
The natural plant compound carvacrol as an antimicrobial and anti-biofilm agent: mechanisms, synergies and bio-inspired anti-infective materials Anna Marchese, Carla Renata Arciola, Erika Coppo, et al. 34(6):630-656
Ureteral stent-associated infection and sepsis: pathogenesis and prevention: a review Kymora B. Scotland, Joey Lo, Thomas Grgic & Dirk Lange 35(1):204-216
Bacillus cereus biofilm formation on central venous catheters of hospitalised cardiac patients Samman Ikram, Adam Heikal, Sarah Finke, et al 35(1):204-216
Combinatorial approaches with selected phytochemicals to increase antibiotic efficacy against Staphylococcus aureus biofilms Ana Cristina Abreu, Maria José Saavedra, Lúcia C. Simões & Manuel Simões 32(9):1103-14
Titanium surfaces immobilized with the major antimicrobial fragment FK-16 of human cathelicidin LL-37 are potent against multiple antibiotic-resistant bacteria Biswajit Mishra & Guangshun Wang 33(7):544-555
Mini-review: Lactoferrin: a bioinspired, anti-biofilm therapeutic M.C. Ammons & V. Copié 29(4):443-55
Antimicrobial photodynamic activity of toluidine blue encapsulated in mesoporous silica nanoparticles against Pseudomonas aeruginosa and Staphylococcus aureus Paramanantham Parasuraman, Asha P. Antony, Sruthil Lal S. B, et al. 35(1):89-103
Biofilm inhibition and anti-quorum sensing activity of phytosynthesized silver nanoparticles against the nosocomial pathogen Pseudomonas aeruginosa Saloni Shah, Swapnil Gaikwad, Shuchi Nagar, et al 35(1):34-49

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