Shifting from chronic management to potential cures: gene therapy and advanced therapeutics in non-malignant hematology

The landscape of non-malignant hematology is undergoing a shift, as advancements in gene therapy and advanced therapeutics pave the way for potential cures rather than lifelong management of chronic conditions. Disorders such as sickle cell disease, hemophilia, and thalassemia (once considered incurable) are now at the forefront of transformative research that aims to correct the underlying genetic defects. With innovations such as CRISPR-based gene editing, viral vector technologies, and cell-based therapies, the promise of durable, one-time treatments is becoming a reality, offering hope to millions who have relied on symptom management for decades.

This Article Collection explores the cutting-edge science driving this revolution, highlighting the clinical breakthroughs, ethical considerations, and patient stories that are reshaping the field. From the challenges of scaling gene therapies to the potential for global accessibility, these articles delve into the complexities and opportunities of shifting from chronic care to curative solutions. Whether you’re a clinician, researcher, or advocate, this collection provides a compelling look at how advanced therapeutics are redefining the future of hematology and transforming lives.

Authors are invited to contribute Editorials, Reviews, Critical Perspectives, and Original Research that highlight the shifting paradigm of non-malignant hematology. By publishing as part of this Article Collection, contributors will join a collaborative effort to drive progress in this vital area of research, ultimately improving the lives of patients worldwide.

The benefit of publishing as part of an Article Collection is that they often become a key resource, driving a research community forward. This has a synergistic effect on every article in the Collection. The articles often receive more views and higher citation numbers as the Collections receive increased promotion via social media and our marketing team. 

If you are interested in contributing, or would like to learn more, then please reach out to the Commissioning Editor, Reegan Burnell-Clarke, who will be happy to assist.