This Special Issue presents the challenges posed by five groups of pathogenic fungus: Histoplasma, Coccidioides, Blastomyces, Paracoccidioides and Cryptococcus. These invasive infections, endemic in the Western Hemisphere, are largely asymptomatic, but nevertheless their burden is quite significant. The reviews in this Special Issue present an up-to-date view of the virulence factors, their structural and immunological properties, and their potential as diagnostic markers and therapeutic targets.
- Joshua Fierer, University of California San Diego, USA
|Sensing the heat and the host: Virulence determinants of Histoplasma capsulatum||Sinem Beyhan & Anita Sil|
|Coccidioides immitis and posadasii; A review of their biology, genomics, pathogenesis, and host immunity||Theo N. Kirkland & Joshua Fierer|
|Turning on virulence: Mechanisms that underpin the morphologic transition and pathogenicity of Blastomyces||Joseph A. McBride MD, Gregory M. Gauthier MD & Bruce S. Klein MD|
|Regulatory T cells in paracoccidioidomycosis||Vera L. G. Calich, Ronei L. Mamoni & Flávio V. Loures|
|The capsule of Cryptococcus neoformans||Arturo Casadevall, Carolina Coelho, Radames J. B. Cordero et al.|