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Emerging and Re-emerging Coronaviruses

Emerging Microbes and Infections

Guest Editor: Dr. Susan R Weiss, Perelman School of Medicine, University of Pennsylvania, USA

Emerging and re-emerging coronaviruses, including Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and the latest “Wuhan Coronavirus” may cause epidemics or potentially pandemics of highly pathogenic human infectious diseases, posing great threats to the global health.

EMI's Special Issue on Emerging and Re-emerging Coronaviruses covers research and review articles on the basic, translational and clinical studies related to these coronaviruses. As an Open Access journal, all articles in EMI are fully downloadable.

ArticleAuthor(s)
Hypothesis for potential pathogenesis of SARS-CoV-2 infection——a review of immune changes in patients with viral pneumoniaLing Lin, Lianfeng Lu, Wei Cao & Taisheng Li
Laboratory Diagnosis of Emerging Human Coronavirus Infections — The State of the ArtMichael J. Loeffelholz & Yi-Wei Tang
The different clinical characteristics of corona virus disease cases between children and their families in China --the character of children  with COVID-1Liang Su, Xiang Ma, Huafeng Yu, Zhaohua Zhang, Pengfei Bian, Yuling Han, Jing Sun, Yanqin Liu, Chun Yang, Jin Geng, Zhongfa Zhang & Zhongtao Gai
Clinical Observation and Management of COVID-19 PatientsTaisheng Li, Hongzhou Lu & Wenhong Zhang
Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2
Jianhui Nie, Qianqian Li, Jiajing Wu, Chenyan Zhao, Huan Hao, Huan Liu, Li Zhang, Lingling Nie, Haiyang Qin, Meng Wang, Qiong Lu, Xiaoyu Li, Qiyu Sun, Junkai Liu, Changfa Fan, Weijin Huang, Miao Xu & Youchun Wang
Emerging WuHan (2019-nCoV) Coronavirus: Glycan shield and structure prediction of Spike glycoprotein and its interaction with Human  CD26Naveen Vankadari & Jacqueline A. Wilce
Era of molecular diagnosis for pathogen identification of unexplained pneumonia, lessons to be learnedJing-Wen Ai, Yi Zhang, Hao-Cheng Zhang, Teng Xu & Wen-Hong Zhang
A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defense: Lessons from other pathogenic virusesSin-Yee Fung, Kit-San Yuen, Zi-Wei Ye, Chi-Ping Chan & Dong-Yan Jin
Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection: an operational recommendation of Peking Union Medical College Hospital (V2.0)Taisheng Li
Timely Development of Vaccines against SARS-CoV-2Shan Lu
Is SARS-CoV-2 originated from laboratory? A rebuttal to the claim of formation via laboratory recombinationPei Hao, Wu Zhong, Shiyang Song, Shiyong Fan & Xuan Li
Public’s early response to the novel coronavirus–infected pneumoniaSiyi Zhan, Ying Ying Yang & Chuanxi Fu
Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severityWeilie Chen, Yun Lan, Xiaozhen Yuan, Xilong Deng, Yueping Li, Xiaoli Cai, Liya Li, Ruiying He, Yizhou Tan, Xizi Deng, Ming Gao, Guofang Tang, Lingzhai Zhao, Jinlin Wang, Qinghong Fan, Chunyan Wen, Yuwei Tong, Yangbo Tang, Fengyu Hu, Feng Li & Xiaoping Tang
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibodyXiaolong Tian, Cheng Li, Ailing Huang, Shuai Xia, Sicong Lu, Zhengli Shi, Lu Lu, Shibo Jiang, Zhenlin Yang, Yanling Wu & Tianlei Ying
No credible evidence supporting claims of the laboratory engineering of SARS-CoV-2Shan-Lu Liu, Linda J. Saif, Susan R. Weiss & Lishan Su
Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes Wei Zhang, Rong-Hui Du, Bei Li, Xiao-Shuang Zheng, Xing-Lou Yang, Ben Hu, Yan-Yi Wang, Geng-Fu Xiao, Bing Yan, Zheng-Li Shi & Peng Zhou
HIV-1 did not contribute to the 2019-nCoV genome Chuan Xiao, Xiaojun Li, Shuying Liu, Yongming Sang, Shou-Jiang Gao & Feng Gao
An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategiesShibo Jiang, Lanying Du & Zhengli Shi
Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018Yanqun Wang, Xin Li, Wenkuan Liu, Mian Gan, Lu Zhang, Jin Wang, Zhaoyong Zhang, Airu Zhu, Fang Li, Jing Sun, Guoxian Zhang, Zhen Zhuang, Jiaying Luo, Dehui Chen, Shuyan Qiu, Li Zhang, Duo Xu, Chris Ka Pun Mok, Fuchun Zhang, Jingxian Zhao, Rong Zhou & Jincun Zhao
Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting WuhanJasper Fuk-Woo Chan, Kin-Hang Kok, Zheng Zhu, Hin Chu, Kelvin Kai-Wang To, Shuofeng Yuan & Kwok-Yung Yuen
Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirusHannah Kleine-Weber, Simon Schroeder, Nadine Krüger, Alexander Prokscha, Hassan Y. Naim, Marcel A. Müller, Christian Drosten, Stefan Pöhlmann & Markus Hoffmann
Genetic manipulation of porcine deltacoronavirus reveals insights into NS6 and NS7 functions: a novel strategy for vaccine designMengjia Zhang, Wan Li, Peng Zhou, Dejian Liu, Rui Luo, Anan Jongkaewwattana & Qigai He
Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camelsWei Zhang, Xiao-Shuang Zheng, Bernard Agwanda, Sheila Ommeh, Kai Zhao, Jacqueline Lichoti, Ning Wang, Jing Chen, Bei Li, Xing-Lou Yang, Shailendra Mani, Kisa-Juma Ngeiywa, Yan Zhu, Ben Hu, Samson Omondi Onyuok, Bing Yan, Danielle E. Anderson, Lin-Fa Wang, Peng Zhou & Zheng-Li Shi
GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virusDanying Chen, Zhifei Hou, Dong Jiang, Mei Zheng, Guoli Li, Yue Zhang, Rui Li, Hanxin Lin, Jinhong Chang, Hui Zeng, Ju-Tao Guo & Xuesen Zhao
Antibodies and vaccines against Middle East respiratory syndrome coronavirusJiuyang Xu, Wenxu Jia, Pengfei Wang, Senyan Zhang, Xuanling Shi, Xinquan Wang & Linqi Zhang
Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoproteinIvy Widjaja, Chunyan Wang, Rien van Haperen, Javier Gutiérrez-Álvarez, Brenda van Dieren, Nisreen M.A. Okba, V. Stalin Raj, Wentao Li, Raul Fernandez-Delgado, Frank Grosveld, Frank J. M. van Kuppeveld, Bart L. Haagmans, Luis Enjuanes, Dubravka Drabek & Berend-Jan Bosch
Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5Patrick CY Woo, Susanna KP Lau, Kenneth SM Li, Alan KL Tsang & Kwok-Yung Yuen
Understanding the T cell immune response in SARS coronavirus infectionHsueh-Ling Janice Oh, Samuel Ken-En Gan, Antonio Bertoletti & Yee-Joo Tan
A camel-derived MERS-CoV with a variant spike protein cleavage site and distinct fusion activation propertiesJean Kaoru Millet, Monty E Goldstein, Rachael N Labitt, Hung-Lun Hsu, Susan Daniel & Gary R Whittaker
Polyphyletic origin of MERS coronaviruses and isolation of a novel clade A strain from dromedary camels in the United Arab EmiratesSusanna K P Lau, Renate Wernery, Emily Y M Wong, Sunitha Joseph, Alan K L Tsang, Nissy Annie Georgy Patteril, Shyna K Elizabeth, Kwok-Hung Chan, Rubeena Muhammed, Jöerg Kinne, Kwok-Yung Yuen, Ulrich Wernery & Patrick C Y Woo
Identification and evolutionary dynamics of two novel human coronavirus OC43 genotypes associated with acute respiratory infections: phylogenetic, spatiotemporal and transmission network analysesXiang Yong Oong, Kim Tien Ng, Yutaka Takebe, Liang Jie Ng, Kok Gan Chan, Jack Bee Chook, Adeeba Kamarulzaman & Kok Keng Tee
Coronavirus HKU15 in respiratory tract of pigs and first discovery of coronavirus quasispecies in 5′-untranslated regionPatrick CY Woo, Susanna KP Lau, Chi-Ching Tsang, Candy CY Lau, Po-Chun Wong, Franklin WN Chow, Jordan YH Fong & Kwok-Yung Yuen
Diversity and role of cave-dwelling hematophagous insects in pathogen transmission in the Afrotropical regionJudicaël Obame-Nkoghe, Eric-Maurice Leroy & Christophe Paupy
Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015Maged Gomaa Hemida, Abdulmohsen Alnaeem, Daniel KW Chu, Ranawaka APM Perera, Samuel MS Chan, Faisal Almathen, Emily Yau, Brian CY Ng, Richard J Webby, Leo LM Poon & Malik Peiris
Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in EgyptMohamed A Ali, Mahmoud M Shehata, Mokhtar R Gomaa, Ahmed Kandeil, Rabeh El-Shesheny, Ahmed S Kayed, Ahmed N El-Taweel, Mohamed Atea, Nagla Hassan, Ola Bagato, Yassmin Moatasim, Sara H Mahmoud, Omnia Kutkat, Asmaa M Maatouq, Ahmed Osman, Pamela P McKenzie, Richard J Webby & Ghazi Kayali
Diversity of Middle East respiratory syndrome coronaviruses in 109 dromedary camels based on full-genome sequencing, Abu Dhabi, United Arab EmiratesMohammed Farouk Yusof, Krista Queen, Yassir Mohammed Eltahir, Clinton R Paden, Zulaikha Mohamed Abdel Hameed Al Hammadi, Ying Tao, Yan Li, Abdelmalik Ibrahim Khalafalla, Mang Shi, Jing Zhang, Muzammil Sayed Ahmed Elhaj Mohamed, Mahmud Hamed Abd Elaal Ahmed, Ihsaan Abdulwahab Azeez, Oum Keltoum Bensalah, Ziyada Swar Eldahab, Farida Ismail Al Hosani, Susan I Gerber, Aron J Hall, Suxiang Tong & Salama Suhail Al Muhairi
Discovery and genetic analysis of novel coronaviruses in least horseshoe bats in southwestern ChinaLihua Wang, Shihong Fu, Yuxi Cao, Hailin Zhang, Yun Feng, Weihong Yang, Kai Nie, Xuejun Ma & Guodong Liang
Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral originsSusanna K. P. Lau, Rachel Y. Y. Fan, Hayes K. H. Luk, Longchao Zhu, Joshua Fung, Kenneth S. M. Li, Emily Y. M. Wong, Syed Shakeel Ahmed, Jasper F. W. Chan, Raven K. H. Kok, Kwok-Hung Chan, Ulrich Wernery, Kwok-Yung Yuen & Patrick C. Y. Woo
A novel human coronavirus OC43 genotype detected in mainland ChinaYun Zhu, Changchong Li, Li Chen, Baoping Xu, Yunlian Zhou, Ling Cao, Yunxiao Shang, Zhou Fu, Aihuan Chen, Li Deng, Yixiao Bao, Yun Sun, Limin Ning, Chunyan Liu, Ju Yin, Zhengde Xie & Kunling Shen
Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese batsDan Hu, Changqiang Zhu, Lele Ai, Ting He, Yi Wang, Fuqiang Ye, Lu Yang, Chenxi Ding, Xuhui Zhu, Ruicheng Lv, Jin Zhu, Bachar Hassan, Youjun Feng, Weilong Tan & Changjun Wang
Human coronavirus OC43 outbreak in wild chimpanzees, Côte d´Ivoire, 2016Livia V. Patrono, Liran Samuni, Victor M. Corman, Leila Nourifar, Caroline Röthemeier, Roman M. Wittig, Christian Drosten, Sébastien Calvignac-Spencer & Fabian H. Leendertz
The emergence of novel sparrow deltacoronaviruses in the United States more closely related to porcine deltacoronaviruses than sparrow deltacoronavirus HKU17Qi Chen, Leyi Wang, Chenghuai Yang, Ying Zheng, Phillip C. Gauger, Tavis Anderson, Karen M. Harmon, Jianqiang Zhang, Kyoung-Jin Yoon, Rodger G. Main & Ganwu Li

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