International Journal of Nanomedicine

Nanobiomaterials (NBMs) are a class of materials that combine the principles of nanotechnology and biomaterials to create innovative solutions for various biomedical applications. They are designed and engineered at the nanoscale level, which typically involves working with materials and structures that range from 1 to 100 nanometers in size. The field of NBMs has gained significant attention in recent years due to its potential to revolutionize medicine and healthcare. NBMs have unique properties and interactions at the nanoscale that make them suitable for a wide range of applications in biology, medicine, and medical devices. Some of the key characteristics and applications of NBMs include:

High surface area: Due to their nanoscale size, NBMs have a large surface area relative to their volume. This property is advantageous for applications such as drug delivery, where increased surface area allows for better drug loading and release kinetics.

Enhanced bioactivity: NBMs can be functionalized with specific molecules to improve their interactions with biological systems, such as cells and tissues. This enables better biocompatibility and targeted delivery of therapeutic agents.

Drug delivery: NBMs can be engineered to encapsulate and deliver drugs, proteins, or genetic material to specific sites in the body. This targeted drug delivery can improve the efficacy of treatments while reducing side effects.

Tissue engineering: NBMs play a vital role in tissue engineering and regenerative medicine. They can serve as scaffolds to support cell growth and tissue formation, facilitating the repair and regeneration of damaged tissues and organs.

Diagnostics: NBMs are utilized in diagnostic applications, such as nanosensors for detecting biomarkers, nanoprobes for imaging, and nanoparticle-based assays for disease detection.

Therapeutics: Some NBMs have inherent therapeutic properties, such as antibacterial nanoparticles that can combat infections or nanoscale materials with photothermal or photodynamic properties for cancer therapy.

Implants and medical devices: NBMs are used in the development of advanced implants and medical devices with improved mechanical properties, biocompatibility, and reduced risk of adverse reactions.

Despite their promising potential, the development and application of NBMs also raise concerns about their long-term safety, toxicity, and environmental impact. As research in this field continues to progress, it is essential to balance innovation with a thorough understanding of the potential risks and benefits associated with these novel materials.

In this Article Collection, the research devoted to the interaction between NBMs and tissue/cell, the effect of size, morphology, shape, and surface of NBMs on their toxicity, biocompatibility, immunogenicity, design of novel biodegradable and biocompatible NBMs, instrumentation, and technologies to analyze biocompatibility of NBMs and challenges to overcome the toxicity of NBMs. This exposure would potentially pave the way for exciting and innovative concepts of NBMs and provide game-changing solutions for several research areas, including tissue engineering, drug delivery, medical devices, biosensors, and other biomedical applications.

This topic covers several successful models of NBMs, including polymer-based NBMs, magnetic and gold nanoparticles, quantum dots, and inorganic-organic-based and carbon nanomaterials (CNMs)-based NBMs, used in biomedical engineering and biosensing applications. We are specifically emphasized in articles narrating the cell and NBMs interaction, toxicity and biocompatibility advancing protocol, structural-property relationship, degradation of NBMs, etc.

The following potential topics are included in this Article Collection but are not limited to:

• Biocompatibility Assessment of NBMs:
• Designing NBMs with multiple functions for medical purposes.
• Developing drug delivery strategies using NBMs as carriers.
• Using in vitro/in vivo approaches to understand the biological effects of NBMs.

Overall, it is hoped that this Article Collection will facilitate the assembling of new collaborations and motivate new generations to engage in the engineering of NBMs for a wide range of applications.

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All manuscripts submitted to this Article Collection will undergo full peer-review; Guest Advisors will not be handling submitted articles. Please review the journal’s aims and scope and author submission instructions prior to submission.

Please submit your manuscript through the Dovepress website. During submission, enter the promo code EJJKG to indicate that your article should be considered for this Collection.

Please contact Haoyang Yi (Commissioning Editor) at [email protected] with any queries regarding this Article Collection.

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Guest advisor

Dr. Narsimha Mamidi, University of Wisconsin-Madison

[email protected]

Dr. Narsimha Mamidi is now serving as Scientist-I at WiscNano, University of Wisconsin-Madison, Wisconsin, USA. His primary research focus revolves around pioneering the development of Nanoformulations for the co-delivery of drugs and genes, with a particular emphasis on cancer immunotherapy. His overarching objective is to advance the application of Nanoformulations for clinical use, revolutionizing the landscape of immunotherapy. This endeavor entails the creation of user-friendly drug delivery platforms tailored for a spectrum of cancer types, including but not limited to triple-negative breast cancer, lung cancer, liver cancer, brain cancer, and pancreatic cancer.

Dr. R.D.K. Misra, University of Texas at El Paso

[email protected]

Dr. Misra is a Professor in the Department of Metallurgical, Materials, and Biomedical Engineering at The University of Texas at El Paso, USA. He is also the Editor-in-Cheif of International Journal of Nanomedicin. His inter-/multidisciplinary research interests include advanced manufacturing of biomedical devices, nanoparticle-systems for drug delivery, antimicrobial systems, super-hydrophobic nanocomposites for wound dressing, nanostructured implants, impact of nanostructured surfaces on protein adsorption, quantum dots for bio-imaging, and bio-nano interactions. His research programs involve the use of a broad spectrum of biomaterials characterization techniques such as electron microscopy, confocal microscopy, X-ray diffraction, EBSD, atomic force microscopy, and mechanical testing, to list a few.

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