The Journal of Maternal-Fetal & Neonatal Medicine

Twin Pregnancy in the 21st Century

Twin pregnancy has become increasingly prevalent in recent decades, largely due to assisted reproductive technologies and advanced maternal age. While multiple gestations represent an extraordinary obstetric scenario, they are also associated with heightened risks for both mothers and babies. Advances in maternal-fetal medicine, neonatal care, and perinatal epidemiology offer new opportunities to better understand and manage these complex pregnancies.

Subtopics for the Article Collection: “Twin Pregnancy in the 21st Century”

1. Epidemiology and Global Trends
   • Changing incidence of twin pregnancies in natural and assisted conceptions
   • Demographic, environmental, and genetic determinants
2. Diagnosis and Prenatal Screening
   • Advances in early ultrasound and chorionicity assessment
   • Non-invasive prenatal testing and twin-specific challenges
3. Maternal Risks and Complications
   • Hypertensive disorders, diabetes, and maternal morbidity
   • Hemorrhage, preterm labor, and cesarean delivery rates
4. Fetal Complications in Twin Pregnancies
   • Twin-to-twin transfusion syndrome (TTTS), selective growth restriction (sFGR), TAPS, and TRAP sequence
   • Strategies for fetal monitoring and intervention
5. Twin molar pregnancy
   • Clinical presentation and diagnostic challenges
   • Management strategies and follow-up protocols
   • Prognostic implications for maternal and perinatal outcomes
6. Twin Pregnancy in Assisted Reproduction
   • Impact of ART on maternal and perinatal outcomes
   • Elective single embryo transfer and policy implications
7. Advances in Fetal Therapy for Twin Pregnancies
   • Fetoscopic surgery and laser therapy in monochorionic gestations
   • Outcomes, complications, and long-term follow-up
8. Timing and Mode of Delivery in Twin Pregnancies
   • Vaginal delivery vs. cesarean section in twin gestations
   • Clinical guidelines and controversies
9. Perinatal and Neonatal Outcomes
   • Preterm birth, low birth weight, and neonatal intensive care
   • Long-term neurodevelopmental outcomes of twins
10. Psychological, Social, and Ethical Aspects
    • Parental experiences and psychosocial impact of twin pregnancies
    • Ethical considerations in selective reduction and complex decision-making
11. Future Directions and Innovations
    • Genomics, biomarkers, and artificial intelligence in twin pregnancy
    • Translational research and multicenter collaborations

This Article Collection welcomes original research, systematic reviews, and clinical case reports addressing the full spectrum of challenges and innovations in twin pregnancy. We invite contributions from clinicians, researchers, and public health professionals working in maternal-fetal medicine, neonatology, reproductive medicine, and related disciplines.

All manuscripts submitted to this Article Collection will undergo a full peer-review; the Guest Advisor for this Collection will not be handling the manuscripts. 

Please review the journal scope and author submission instructions prior to submitting a manuscript. 

The deadline for submitting manuscripts is July 31^st, 2026.

Please contact Menghan Li at [email protected]  with any queries and discount codes regarding this Article Collection.

Please be sure to select the appropriate Article Collection from the drop-down menu in the submission system.