Clinical Ophthalmology

The Choroid in Health and Disease

The investigation of choroidal dynamics has been gaining increasing and critical interest in the recent years due to its pervasive involvement in the pathogenesis and progression of numerous sight-threatening chorioretinal disorders. Choroidal structural, circulatory, or inflammatory perturbations are now recognized as a core etiology in multiple conditions including age-related macular degeneration, pathological myopia, central serous chorioretinopathy and related pachychoroid disorders, hypertensive and diabetic eye disease, and diverse posterior uveitides.

Crucially, the recent advancements of non-invasive imaging modalities, notably swept-source optical coherence tomography (OCT) and widefield OCT, has propelled in vivo assessment of the choroid, facilitating quantitative analysis of its thickness, vasculature, and underlying morphological changes. This technological leap now facilitates essential quantitative analysis of its thickness, vasculature, and underlying morphological changes. These tools are the foundation for the next generation of diagnostics and treatment monitoring.

This Article Collection, "The Choroid in Health and Disease", aims to gather cutting-edge research illuminating the complex physiological and pathological states of this essential tissue. We solicit contributions covering the latest advancements in:

• Quantitative choroidal imaging and biometrics
• The choroid's role in the refractive error pathway and myopia control
• Choroidal vascular alterations in systemic conditions
• The mechanistic contribution of choroidal changes to macular pathologies
• Novel insights into choroidal inflammation, immunology, and targeted therapeutics

We welcome the submission of original research articles, rigorous systematic reviews, and technically-focused brief reports that contribute significantly to the molecular, structural, and clinical understanding of choroidal biology.

Submission Instructions:

Please submit your manuscript through the Dovepress website. During submission, enter the promo code 61088 for a 10% discount off the Article Processing Charge and to indicate that your submission should be included in this Article Collection.

All manuscripts submitted to this Article Collection will undergo full peer-review; Guest Advisors will not be handling submitted articles. Please review the journal’s aims and scope and author submission instructions prior to submission. Standard Article Publishing Charges apply.

The manuscript submission deadline is 1 August 2026.

If you have any questions about this Article Collection, please contact Krista Thom at [email protected].

Guest Advisors:

Dr. Yousef Fouad is a Retina Consultant and Lecturer in the Department of Ophthalmology at Ain Shams University in Cairo, Egypt, holding an M.D. and FRCS (Glasg.). His research heavily focuses on medical retina and imaging, frequently utilizing Optical Coherence Tomography (OCT) to study macular pathologies and choroidal thickness. He has published over 60 research articles and multiple book chapters. He serves as Retina Section Editor for the journal Clinical Ophthalmology, as well as sitting on the editorial and reviewer boards of multiple peer-reviewed journals. He has received several national and international awards/grants including from USAID, FloRetina, and ARVO.

Dr. Sumit Randhir Singh is a vitreo-retinal consultant at Akhand Jyoti Eye Hospital in Mastichak, Saran, Bihar, India. He completed his medical degree and residency in ophthalmology at JIPMER, Puducherry, India. He pursued further specialization with a fellowship in Vitreoretina & Uveitis at L V Prasad Eye Institute, followed by a research fellowship at the Jacobs Retina Center, University of California, San Diego, USA. Dr. Singh's main areas of expertise and interest include macular disorders and advanced imaging modalities like Optical Coherence Tomography (OCT), OCT angiography, and chorioretinal imaging biomarkers. He is an accomplished researcher with more than 125 PubMed-indexed articles and book chapters to his credit.

Disclosure Statement: Neither Dr. Fouad nor Dr. Singh declares any conflict of interest.