Renal Failure

The global surge in the incidence and prevalence of diabetes is a growing concern, with an estimated 537 million individuals affected by type 2 diabetes worldwide, a number expected to rise to 783 million by 2045. Diabetes stands as the leading cause of chronic kidney disease globally, with approximately 30% of diabetics anticipated to develop diabetic kidney disease. Concurrently, hypertension, another major risk factor for kidney disease, shares common ground with diabetes, jointly contributing to over 50% of kidney-related issues. This escalating burden not only impacts public health but also carries a substantial economic cost, with the estimated economic burden of kidney disease in the UK reaching £7.0 billion.

As pivotal factors that influence the trajectory of renal health, the management of diabetes and hypertension is vital due to their prevalence, clinical implications, interdisciplinary relevance, and potential for shaping the future of kidney care. This article collection seeks to showcase the latest research, laying the foundation for breakthroughs and innovations in renal medicine. The primary focus lies in the interplay between these major risk factors, exploring preventive strategies and advancing the understanding and application of therapies for chronic kidney disease, acute kidney injury, dialysis, or transplantation.

Therefore, we want to invite authors to submit a range of contributions, including original research, case series, state-of-the-art reviews, and opinion pieces highlighting progress in diabetes and hypertension-related kidney disease. The focus areas for submissions include but are not limited to:

1. Diabetes and kidney diseases:

• Novel pathogenetic insights
• Future therapies
• Diabetic kidney disease (DKD) prognostic indices
• Relationship between DKD and cardiovascular disease
• Cellular mechanisms of SGLT2i in attenuating DKD
• Novel uses of SGLT2i
• SGLT2i and its benefit in transplantation
• Gut microbiota in DKD
• Animal models
• Serum and urine biomarkers
• MicroRNAs in DKD pathogenesis and treatment
• DKD 'Omics': proteomics, peptidomics, metabolomics, genomics
• Post-transplant diabetes: pathogenesis and management
• Pancreas and islet transplantation
• Artificial intelligence and its role in diabetes management

2. Hypertension and kidney diseases:

• Mechanisms of hypertension-induced renal damage
• Innovative approaches in hypertension management for kidney health
• Prognostic markers for hypertensive nephropathy
• Interplay between hypertension and renal function decline
• Novel therapeutic targets for hypertensive kidney diseases
• Genetic and environmental factors influencing hypertension-related kidney damage
• Hypertension-associated microvascular changes in the kidneys
• Biomarkers for early detection and monitoring of hypertensive nephropathy
• Integrative 'Omics' approach in understanding the complex relationship between hypertension and kidney diseases
• Development of hypertension in kidney donors
• Post-transplant hypertension
• Newer therapies
• Serum and urine biomarkers
• Artificial intelligence and its role in diabetes management

Keywords: Chronic kidney disease, Diabetes, Hypertension, Acute Kidney Injury, Transplantation

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Guest Advisors

Dr. Hatem Ali, M.D. is a final-year trainee in renal and General Internal Medicine in the UK, currently pursuing a Ph.D. on predictive models for kidney graft survival using Artificial Intelligence. Holding a master's degree in Transplantation Sciences from the University of Liverpool, he possesses expertise that spans the intricate intersection of diabetes, hypertension, and renal health. With a focus on advancing predictive models in renal medicine, Dr. Ali brings a wealth of knowledge and experience to the forefront of research. His prior work includes a comprehensive exploration of immunosuppressive therapies and their impact on renal transplantation outcomes. As an active contributor to the field, Dr. Ali strives to unravel the complexities of the diabetes and hypertension nexus, fostering collaboration and advancing our understanding of predictive modeling in renal health.

Dr. Shafi Malik, M.D. is a transplant nephrologist at Queen Elizabeth Hospital, Birmingham. He brings a wealth of expertise to the role of Guest Editor. He has completed a clinical research training program at Harvard Medical School, demonstrating his commitment to advancing medical knowledge. Dr. Malik has a keen interest in clinical epidemiology and research within transplantation. His academic roles include organizing courses on epidemiology and biostatistics, question writing for the Royal College of Physicians UK, and serving as an examiner for PLAB and Warwick Medical School. Additionally, he has published a preparatory book for the ESENeph exam. Furthermore, he is an Associate Editor for a Royal College of Physicians journal. His current research interests encompass health outcomes-based research, the promotion of living donation in ethnic minorities, cognition in transplant recipients, and live donor outcomes, among other areas. Driven by a commitment to advancing medical knowledge, he maintains ongoing collaborations with fellow researchers and has successfully secured grants from both commercial and charity organizations. Additionally, he actively contributes as a community member to the UK Emergency Medical Team.

Disclosure Statement: Both Dr. Hatem Ali and Dr. Shafi Malik declare there is no conflict of interest.

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All manuscripts submitted to this Article Collection will undergo a full peer-review; the Guest Advisor for this Collection will not be handling the manuscripts (unless they are an Editorial Board member).

Please review the journal scope and author submission instructions prior to submitting a manuscript.

The deadline for submitting manuscripts is September 30th, 2024.

Please contact Ruby Ru at [email protected] with any queries and discount codes regarding this Article Collection.

To submit your papers to this Article Collection, please:

1. Check "yes" for the question, "Are you submitting your paper for a specific special issue or article collection?"
2. Select the relevant Article Collection from the drop-down menu under the question, "Special Issue or Article Collection Name."

Instructions for AuthorsSubmit an Article