Journal of Enzyme Inhibition and Medicinal Chemistry

Peptidomimetics as Potential Therapeutic Agents

Peptidomimetics are synthetically engineered molecules designed to mimic the structure and function of conventional peptides, with the aim of overcoming drawbacks associated with conventional peptides such as poor stability, bioavailability, selectivity, and activity. Peptidomimetics achieve enhanced aforementioned properties through a wide range of chemical modifications, including macrocyclization, side chain alterations, unnatural molecular scaffold or new molecular framework. This collection aims to highlight peptidomimetics as potential therapeutic agents to combat diseases including but not limited to cancer, diabetes, neurodegenerative diseases, and infectious diseases.

Regular peptides are important modalities for therapeutic development, yet their susceptibility to proteolytic degradation, poor stability and bioavailability, hampering their wide application. Peptidomimetics could overcome the limitations of regular peptides by introducing synthetic scaffolds and enhancing chemical functional diversity. Some peptidomimetics are already approved by FDA, highlighting their importance and promising future.

The scope this collection is broad. Any topics related to potential therapeutic potential of peptidomimetics will be considered, including peptidomimetics targeting cancer, diabetes, neurodegenerative diseases, infectious diseases, and others. The article types can be research article or review.

Please submit your manuscript on our website, using the promo code IENZ-2026-C41338 for 10% off the advertised article processing charge and selecting the corresponding Article Collection title in the drop-down menu through the submission process to indicate that your manuscript will be considered for the “Peptidomimetics as Potential Therapeutic Agents” Collection.

Please contact Haoyang Yi (Commissioning Editor) at [email protected] with any queries regarding this Article Collection.

Guest Advisors

Prof. Jianfeng Cai

Jianfeng is a Preeminent and Distinguished University Professor and the Julie Harmon Endowed Chair in Chemistry at the University of South Florida. He has the research interest on the development of AApeptides, a class of peptidomimetics, for their application in cancer, diabetes, AD, etc.

Prof. Peng Sang

Peng is a Professor at the School of Pharmaceutical Sciences, Zhengzhou University. He has the research interest on the development of peptidomimetics for their application in cancer, diabetes, AD, etc.

Prof. Yan Shi

Yan is a Professor at the School of Pharmaceutical Sciences, Zhengzhou University. She has the research interest on the development of peptidomimetics for their application in cancer, diabetes, AD, etc.