Epilepsy is a neurological disorder that affects a substantial number of individuals worldwide, with more than 70 million individuals suffering from this condition. It is considered to be one of the most common serious diseases of the central nervous system. The incidence of epilepsy shows a bimodal distribution, meaning that the highest risk of developing the disorder is observed in infants and older age groups. The clinical presentation of epilepsy can vary greatly from person to person, resulting in diverse symptoms and manifestations. These variations can have a profound impact on the patients’ quality of life, affecting their daily activities, social interactions, and overall well-being.
For clinical approaches, investigations such as brain imaging and genetic testing could aid in identifying the underlying etiologies and predicting the prognosis. In recent years, the field of precision medicine has gained significant attention in the context of epilepsy. Through the discovery of genes associated with these disorders, researchers have been able to advance their understanding of the underlying biology and pathogenesis of epilepsy. This newfound knowledge has opened up possibilities for developing targeted therapies that can modify or even cure the condition. The advances in brain imaging techniques have also played a significant role in epilepsy research. These imaging modalities, including structural magnetic resonance imaging (MRI), functional MRI (fMRI), and positron emission tomography (PET) have enabled researchers to identify structural and functional abnormalities in the brain that may be responsible for causing or contributing to epileptic seizures.
Furthermore, an improved understanding of the gradual development of epilepsy, as well as the role of epigenetic factors and pharmacogenomics, has offered hope for the development of better therapeutic strategies. Researchers are exploring both pharmacological and non-pharmacological approaches to treat epilepsy, with the aim of improving patient outcomes and enhancing their quality of life. This Article Collection will focus on the latest research progress in epilepsy diagnosis and treatment. It will cover topics such as clinical observational study, neuroimaging study, genetic analysis, mechanism research, prospects for further targeted treatment, and rehabilitation interventions. By highlighting these advances, the collection aims to provide valuable insights for clinicians, researchers, and patients alike personalized approaches for managing epilepsy.
Keywords:
• Epilepsy
• Diagnostic and therapeutic strategies
• Neuroimaging
• Genetic analysis
• Targeted treatment
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