Journal of Inflammation Research

Inflammation is an adaptive response and integral part of animal biology against a myriad of factors including infection, trauma, and disease. Considerable progress has been made in understanding the cellular and molecular events that are involved in the acute inflammatory response to infection and, to a lesser extent, tissue injury and chronic inflammation.

Numerous studies have shown how the clinical manifestation of inflammation can also be pathological and prime the tissue niche for the progression of myriad complex diseases such as cancer, microbial resistance, autoimmune disorders, and gut microbiota dysbiosis.

Interestingly, several genome-wide association studies (GWAS), whole-exome sequencing (WES), and single cell-based technologies have highlighted how rare genetic mutations or variations modulate the susceptibility of an individual to infectious pathogens, such as Mycobacterium tuberculosis (TB), Human Immunodeficiency Virus (HIV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), by influencing pathological inflammation at a genetic level.

In addition to the genetic determinants, inflammation can also be triggered by multiple non-genetic factors including the microbiome, toxic compounds, diet, and stress, which affect the epigenome and secretome of the tissue microenvironment.

Altogether, these genetic and non-genetic networks in inflammatory diseases have long been established in several clinical and epidemiological studies. However, we still lack a significant understanding of causal links and strategic explanations for the interaction between genome, epigenome, microbiome, metabolome, and inflammatome. Therefore, we need a cohesive approach focusing on both genetic and non-genetic determinants to curb pathological inflammation.

In this Article Collection, we welcome the submission of original research articles and reviews on topics including:

1. Mechanisms of inflammation and inflammatory responses in a variety of diseases.
2. Molecular and computational methodologies to identify new genetic variants linked to the cause and consequences of inflammatory diseases.
3. Novel molecular approaches to identify targets of translational and pathological inflammation.

Conflict of Interest: The Guest Advisors declare no conflicts of interest.

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Submission Instructions:

All manuscripts submitted to this Article Collection will undergo a full peer-review; the Guest Advisors will not be handling the manuscripts. Please review the journal’s aims and scope and author submission instructions prior to submitting a manuscript.

During submission, enter the promo code PQCII to indicate that your submission should be considered for this Collection. Promo codes are used to identify articles that belong to a specific Collection, so it is important to use the correct code.

The deadline for submitting a manuscript is 15 December 2023. If you have questions, please contact Krista Thom at [email protected].

Instructions for AuthorsSubmit an Article