Journal of Inflammation Research

Cellular and Molecular Drivers of Lung Inflammation in Respiratory Diseases

The Journal of Inflammation Research, together with Guest Advisors Dr. Nilesh Sudhakar Ambhore and Senior Graduate Student Ashish Kumar, is pleased to invite you to submit your research to the upcoming Article Collection “Cellular and Molecular Drivers of Lung Inflammation in Respiratory Diseases”.

Lung inflammation is a hallmark characteristic feature of many respiratory diseases, from asthma and chronic obstructive pulmonary disease (COPD) to pulmonary fibrosis and acute respiratory distress syndrome (ARDS). While inflammation serves as a protective role in response to infection or injury, dysregulated or persistent inflammatory responses can lead to progressive lung damage and impaired respiratory structure and function. Understanding the cellular and molecular drivers behind lung inflammation is crucial for developing targeted therapies that can modulate these pathways without compromising host defense. This topic explores the intricate network of immune and structural cells, signaling pathways, and other cofounding factors that orchestrate inflammatory responses in the lung. This study will offer valuable insight into both disease mechanisms and potential intervention points.

This topic is important because it establishes the foundational understanding of lung inflammation, a key driver of the onset, progression, and severity of numerous respiratory diseases that together pose a significant global health burden.

Studying this topic also matters as it provides following additional advantages:

• Better Understanding of Disease Mechanisms
• Development of Targeted Therapies
• Early Diagnosis and Biomarkers Tools
• Understanding Environmental and Infectious Triggering Agents

The subject of this Collection, "Cellular and Molecular Drivers of Lung Inflammation in Respiratory Diseases," explores the complex cellular and molecular processes that drive and regulate lung inflammation. It covers key subtopics including immune cell activation, structural cells dysfunction, cytokine and chemokine signaling, and the impact of environmental and infectious triggers on pulmonary inflammation. Special attention will also be given to emerging therapeutic targets and biomarker discovery. This scope is well-aligned with the Journal of Inflammation Research, which emphasizes cutting-edge studies on inflammation-related processes. The ail of this collection will be to encourage the submission of original research articles, comprehensive reviews, and brief reports that will provide new insights into the cellular and molecular understanding of lung inflammation in both acute and chronic respiratory diseases.

Upon submission, please use the promo code 4D58A for 10% off the advertised article processing charge and indicate that your manuscript will be considered for the “Cellular and Molecular Drivers of Lung Inflammation” Collection. Please contact the Commissioning Editor, Ashley Ambros, with any questions concerning this Collection.

Keywords: Lung inflammation; respiratory diseases; immune cell signaling; cytokines; chemokines; biomarkers of lung disease

Dr. Nilesh Sudhakar Ambhore is a dedicated and self-motivated research scientist with over 8 years of extensive experience in pharmacology, molecular biology, small molecule drug discovery, and target validation. His proven expertise encompasses the entire preclinical drug development process, including development of in vivo disease models, mechanism of action investigation, endpoint analysis, and disease modeling.

Ashish Kumar is a Doctoral Graduate Research Assistant in pharmaceutical sciences, specializing in the pathophysiology of asthma. His research explores the dynamic relationship between lung physiology and hormonal influences in disease conditions, aiming to advance respiratory pharmacology and personalized medicine.