Submit a Manuscript to the Journal
Journal of Inflammation Research
For an Article Collection on
Bone-Immune System Crosstalk in Musculoskeletal Health and Disease
Manuscript deadline
Article Collection Guest Advisor(s)
Dr. Yan Chen,
The First Affiliated Hospital of Guangxi Medical University
[email protected]
Bone-Immune System Crosstalk in Musculoskeletal Health and Disease
The Journal of Inflammation Research is pleased to welcome you to submit your research to the Article Collection "Bone-Immune System Crosstalk in Musculoskeletal Health and Disease".
Acute inflammation is a fundamental reparative response to injury in musculoskeletal tissues, orchestrating the recruitment of immune cells and the coordinated activity of osteoblasts, osteoclasts, and chondrocytes to remodel and restore damaged bone and cartilage. This intricate process is governed by a sophisticated network of immune signaling pathways and immunometabolic cues, maintaining a delicate homeostatic balance. The emerging field of osteoimmunology is dedicated to deciphering this critical crosstalk.
A bidirectional and dynamic dialogue between hematopoietic immune cells and resident skeletal cells is essential for effective tissue repair and the maintenance of musculoskeletal health. Disruption of this communication—whether by genetic predisposition, chronic inflammation, metabolic dysfunction, or pathogen invasion—can tip the balance from regenerative healing to pathological tissue destruction. This dysregulation lies at the heart of numerous debilitating conditions, leading to chronic pain, loss of function, and significant morbidity, underscoring an urgent need for deeper mechanistic understanding.
The goal of this Article Collection is to bring to light the pivotal role that bones and the musculoskeletal system play in health and disease, and the translational implications of osteoimmunology, immunometabolism, and inflammation-mechanobiology. Key topics include, but are not limited to:
- Coordination of inflammatory processes and skeletal/immune cells involved in bone tissue repair
- Conditions such as osteoarthritis and osteoporosis, characterized by inflammation and destruction of bone and cartilaginous tissue
- Bone and joint infections such as septic arthritis and osteomyelitis
- Arthritic conditions such as rheumatoid arthritis, spondyloarthritis (including ankylosing spondylitis), and gout/gouty arthritis
Keywords: Osteoimmunology; Bone-Immune Crosstalk; Musculoskeletal Inflammation; Arthritis; Bone tissue repair
Meet the Guest Advisor
Dr. Yan Chen is an orthopedic surgeon and Associate Editor of the Journal of Inflammation Research. His research focuses on osteoimmunology, bone regeneration, and mechanobiology of the bone marrow microenvironment. He has led multiple translational research projects exploring bone–immune interactions in musculoskeletal diseases and serves as a reviewer and editor for several international journals. His work integrates clinical orthopedics with cutting-edge molecular and spatial technologies to advance understanding of skeletal inflammation and repair.
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All manuscripts submitted to this Article Collection will undergo desk assessment and peer-review as part of our standard editorial process. Guest Advisors for this Collection will not be involved in peer-reviewing manuscripts unless they are an existing member of the Editorial Board. Please review the journal Aims and Scope and author submission instructions prior to submitting a manuscript.
Submission Instructions
The deadline for submitting manuscripts is 1st February 2027.
Please contact Ashley Ambros at [email protected] with any questions or requests for discount codes relating to this Article Collection.
Please be sure to select the appropriate Article Collection from the drop-down menu in the submission system.