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Journal of Immunotoxicology

For an Article Collection on

Mechanistic Contributions of the Skin to Immunotoxicity

Manuscript deadline
26 January 2024

Cover image - Journal of Immunotoxicology

Article collection guest advisor(s)

Stacey Anderson, National Institute for Occupational Safety and Health (NIOSH)
[email protected]

Lisa Weatherly, National Institute for Occupational Safety and Health (NIOSH)
[email protected]

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Mechanistic Contributions of the Skin to Immunotoxicity

The skin, the largest organ in the body, plays an essential role as a physical barrier acting as an initial defence against foreign molecules, including chemicals and pathogens.  It is increasingly being recognized that the skin is a critical component of the immune system and contains a variety of different mediators responsible for surveillance of and reaction to foreign agents.  Exposure to chemicals commonly occurs through the skin and is known to contribute to a variety of immune related health effects including allergic disease, suppression, autoimmunity and toxicity.   However, the interplay between the skin and immune system and its contribution to human disease is an active area of research and its overall role in the contribution of immunotoxicity has been underrecognized.

Increasing research has suggested that the microenvironment of the skin can influence the development of immune diseases and a variety of events, including release of danger signals, inflammasome signalling, upregulation of proinflammatory cytokines, diversity of microbiota, alterations in skin integrity and permeability, and changes in or contribution of novel immune cell populations.  While the field of immunology continues to evolve, so does our knowledge of the mechanistic contribution of the skin in immunotoxicity. Therefore, investigating the interplay of the skin and immune system may improve the understanding of mechanisms of immunotoxicity.

We invite authors to consider submitting manuscripts focusing on research investigating the interplay of the skin and immune system, including descriptive and mechanistic studies. Original research manuscripts and reviews will be considered, and all manuscripts will be reviewed by qualified reviewers and accepted articles will be published online as gold open access after proofing and formatting.


Dr. Stacey Anderson is a Research Biologist in the Allergy and Clinical Immunology Branch of the National Institute for Occupational Safety and Health (NIOSH). She is an Adjunct Assistant Professor in the Immunology Department at West Virginia University (WVU) and is active within the Society of Toxicology. Her laboratory’s research program focuses on functional effects of occupational chemicals on the immune system and with an emphasis on the dermal route of exposure. A major emphasis of her current research program is on effects of per- and polyfluoroalkyl substances (PFAS) on the immune system following dermal exposure.

Dr. Lisa Weatherly is an Associate Service Fellow in the Allergy and Clinical Immunology Branch of the National Institute for Occupational Safety and Health (NIOSH).  Her graduate work focused on the molecular mechanisms underlying effects of antibacterial agents on cellular signalling and mitochondrial function.  Her post-doctoral work, in the lab of Dr. Stacey Anderson, focuses on the evaluation of dermal exposure of occupational chemicals and the role of the skin and mitochondria in the development of allergic disease.  The current chemicals of interest are per- and polyfluoroalkyl substances (PFAS).


All manuscripts submitted to this Article Collection will undergo a full peer-review; the Guest Advisors for this collection will not be handling the manuscripts (unless they are Editorial Board members).

Please review the journal scope and author submission instructions prior to submitting a manuscript.

Please contact Autumn Zellers at [email protected] with any queries regarding this Article Collection.

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All manuscripts submitted to this Article Collection will undergo desk assessment and peer-review as part of our standard editorial process. Guest Advisors for this collection will not be involved in peer-reviewing manuscripts unless they are an existing member of the Editorial Board. Please review the journal Aims and Scope and author submission instructions prior to submitting a manuscript.