ImmunoTargets and Therapy

Treating Comorbid Immune-Mediated Diseases with Immunotherapy

ImmunoTargets and Therapy is pleased to announce a new Article Collection dedicated to examining immunotherapy strategies to treat comorbid immune-mediated diseases.

Patients with comorbid immune-mediated diseases have at least two or more autoimmune, allergic, infectious or inflammatory diseases that significantly impact their quality of life. Some conditions typically co-occur together, such as Sjogren’s Syndrome and Systemic Lupus Erythematosus. Other diseases may be a result of shared inflammatory signaling pathways or caused by the primary immune-mediated disease. Treating patients with comorbid immune-mediated diseases presents a unique challenge, as treatment may require a multidrug regimen with multiple opportunities for drug interaction.

In this Article Collection, we seek to explore the mechanistic underpinnings of immune-mediated disease comorbidities and potential opportunities for immunotherapeutic treatment. While this call is open to receive manuscripts highlighting all aspects of comorbid immune-mediated disease therapy, the Editors are particularly interested in manuscripts relating to the following areas:

• Cell-based therapeutics such as stem cell and CAR-T cell-mediated therapies
• Novel preclinical models, shared disease pathway targets, and mechanism of action studies
• Emerging immunotherapeutic treatment options and strategies
• Clinical management strategies such as combination therapy and therapeutic resistance
• Special patient populations, including immune disorders involving multiple systems
• Immune-related adverse events while treating comorbid diseases
• New use cases for already-approved immunotherapy to target multiple disease pathways
• Regulation of immunological balance in treating comorbid diseases

Please submit your paper on our website, quoting the promo code 86788 to indicate that the paper is intended for the Article Collection. The deadline for submitting manuscripts is 1 June 2026. If you have any queries regarding the Article Collection, available discounts, or you would like to discuss a submission, then please email the Commissioning Editor Ashley Ambros.

All manuscripts submitted to this Article Collection will undergo desk assessment and a full peer-review. Please review the journal scope and author submission instructions prior to submitting a manuscript as it will be rejected if it does not fall within the scope of the journal.

The deadline for submitting manuscripts is 1^st of June 2026.

Keywords: Comorbidities; immune-mediated diseases; autoimmune disease; immunological balance