Gut Microbes Reports

The commensal microbiota is now understood to have a causative role in the development, progression, and treatment of cancers. Data from human trials, preclinical murine work, and basic and translational in vitro platforms have revealed likely mechanistic associations e.g., Helicobacter pylori in stomach cancer or pks⁺ Escherichia coli in colon and rectal cancers. These observations have led to a search for biomarkers in terms of taxa associated with better or worse outcomes. However, functional redundancy among bacteria has confounded these efforts, and increasing attention is focused on the specific roles of microbial metabolites in oncogenic processes.

In this collection, we seek to highlight articles that describe novel associations between the microbiome, their metabolites, and their interaction with the host. Correlative and observational studies that lead toward translational and mechanistic insights are encouraged, in addition to studies of geographic differences or those associated with differing demographic and cultural patterns. We also hope to highlight relationships between the microbiota and non-gastrointestinal cancers, especially in organs previously thought to be sterile, including the pancreas and lungs.

Topics may include (but are not limited to):

• Novel studies of microbial translocation from one body component to another
• Linking functional datasets (e.g., metagenomics, metatranscriptomics, or proteomics) to microbiome-cancer relationships
• Descriptions of microbiome-cancer associations in understudied populations
• New frameworks or computational approaches to study the roles of the microbiome in cancer onset, progression, or treatment
• Novel microbiota-based therapeutic strategies

Instructions for Authors

The following Article Types will be considered: Research Articles, Review Articles, Systematic Reviews, Case Reports, Rapid Communications, Methods, Data Notes, Registered Reports, and Comments.

When submitting your article, please select the Article Collection, ‘Microbiome and Solid Cancers’ from the drop-down menu on the submission system.

Instructions for AuthorsSubmit an Article