Molecular and Cellular Biology

Functional communication between mitochondria and other organelles in lipid metabolism

Lipid metabolism, mitochondrial function, and the interactions between mitochondria and other organelles are crucial for maintaining cellular homeostasis and energy production. Lipids exert multiple functions, acting as both energy reserves and essential components of cellular membranes and signalling molecules. Mitochondria play a key role in energy metabolism by facilitating ATP production through oxidative phosphorylation, while also involving in lipid degradation and synthesis. Lipid droplets are dynamic organelles that play a crucial role in lipid storage, energy balance, and cell signalling. The endoplasmic reticulum (ER) is the primary site for synthesizing lipids, including triglycerides (TG) and phospholipids. These lipids are essential for forming the core of lipid droplets.

The connections between mitochondria and other organelles, such as lipid droplets, the endoplasmic reticulum, and peroxisome are vital for maintaining lipid balance and ensuring effective responses to diverse cellular stimuli. Dysregulation of these processes can result in metabolic disorders, neurodegenerative diseases, and various other health issues. Understanding the fundamental principles of lipid metabolism and organelle interactions is crucial for developing effective therapeutic strategies.

We invite researchers to submit original research articles, reviews, and commentaries on the interplay between lipid metabolism, mitochondrial function, and organelle interactions for an upcoming Article Collection of Molecular and Cellular Biology (MCB).

Topics of Interest:

• Mechanisms of lipid metabolism and their regulation in cellular contexts
• The role of mitochondria in lipid homeostasis and energy metabolism
• Interactions between mitochondria and other organelles (e.g., endoplasmic reticulum, lipid droplets, and peroxisomes) and metabolic consequences
• Impact of organelle communication on metabolic diseases, aging, and neurodegeneration
• New methodologies for studying lipid dynamics and organelle interactions, including high-resolution imaging techniques, lipidomics, proteomics, and metabolomics
• Therapeutic implications of targeting lipid metabolism and mitochondrial function

All submissions will undergo peer review to ensure the highest quality of publication. Accepted papers will contribute to our understanding of the critical roles that lipid metabolism and organelle interactions play in cellular physiology and disease.

We look forward to your contributions that will enhance our understanding of these essential biological processes!

5 Keywords:

1. Lipid Signalling
2. Mitochondria
3. Organelle Cross-talk
4. Energy Balance
5. Metabolic Disorders

Guest Advisor

Dr. Sun is a tenured Associate Professor at the University of Texas Health Science Center in Houston. His research over the past ten years has focused on mitochondrial dynamics and lipid droplet-associated proteins. He has identified several novel enzymes that translocate to lipid droplets in response to cellular stimuli. Currently, he is using advanced techniques to explore the mechanisms of these factors and their potential clinical implications for metabolic diseases and cancer. For further details about Dr. Sun's professional profile, kindly refer to the links: https://med.uth.edu/imm/2023/07/07/kai-sun-md-phd/, https://orcid.org/0000-0002-4778-4549

Disclosure Statement: Dr. Kai Sun has no conflicts of interest to disclose.

Please review the journal scope and author submission instructions prior to submitting a manuscript.

To submit your papers to this Article Collection, please:

1. Check "yes" for the question, "Are you submitting your paper for a specific special issue or article collection?"
2. Select the Article Collection "Functional communication between mitochondria and other organelles in lipid metabolism" from the drop-down menu under the question, "Special Issue or Article Collection Name."

Please contact Changluan Zhou at changluan.zhou@taylorandfrancis.com with any queries and discount codes regarding this Article Collection.