Eye and Brain

In the human and mouse genomes there are more than 1800 DNA-binding transcription factors. At least 1000 genes are required for the normal development of the eye. It is now established that several transcription factors are of crucial importance for the normal development of specific retinal cells and functions.

However, less is known about the role of these transcription factors in eye diseases affecting the retina, the cornea, and other parts of the eye. There is an increasing literature on the consequences of mutations in transcription factors involved in eye development in both mouse models and in human eye diseases. Still, there are many issues concerning the clinical and biological implications of these mutations that are unresolved.

This Article Collection is intended to be a platform for experts in transcription factors involved in eye development to address the role of these genes in both the normal function of the eye and in eye diseases using the available methods.

We welcome original research articles, reviews, expert opinions, and commentaries.

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Submission Instructions:

During submission, enter the promo code AZQOC to indicate that your submission should be considered for this Collection. Promo codes are used to identify articles that belong to a specific Collection, so it is important to use the correct code.

The deadline for submitting a manuscript is 1 September 2024. If you have questions, please contact Krista Thom at [email protected].

All manuscripts submitted to this Article Collection will undergo a full peer-review; the Guest Advisors will not be handling manuscripts. Please review the journal’s aims and scope and author submission instructions prior to submitting a manuscript.

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Guest Advisors:

Thor Eysteinsson was born and raised in Reykjavik, Iceland, and completed his undergraduate studies at the University of Iceland. In 1987, he defended his Ph.D. thesis on suppressive rod-cone interactions in the retina at the City University of New York, USA. In 1990, he returned to the University of Iceland as an Associate Professor of Physiology. In 2009, he became a Full Professor, and since 2018 he has served as the Head of the Department of Physiology at the University of Iceland.

Andrea Garcia-Llorca was born in Alicante, Spain. She completed undergraduate degrees in Molecular Biology and Biochemistry at the IE University of Segovia and the University of Salamanca respectively. She earned her master’s degree from the University of Salamanca in 2013, then moved to the University of Iceland for her Ph.D. studies. In 2020, she defended her Ph.D. thesis on the role of microphthalmia-associated transcription factor (Mitf) in mouse eye function under the supervision of Prof. Thor Eysteinsson. Andrea currently works as a postdoctoral fellow at the Department of Physiology, University of Iceland where she investigates Mitf mutations with impaired autophagy and retinal disease.

Disclosure Statement: Prof. Eysteinsson and Dr. Garcia-Llorca declare no conflict of interest.

Instructions for AuthorsSubmit an Article