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Epigenetics: Epigenetics in Cardiovascular Health, Pathology, and Development

Manuscript deadline
14 January 2025

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Article collection guest advisor(s)

Assistant Professor. Manuel Rosa-Garrido, The University of Alabama at Birmingham
[email protected]

Senior Scientist Luis Hortells, University of Freiburg
[email protected]

Associate Instructor Marta W. Szulik, University of Utah
[email protected]

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Epigenetics: Epigenetics in Cardiovascular Health, Pathology, and Development

In this article collection, we call for both original research articles and reviews, and invite our contributors to present a comprehensive elucidation about broadly understood cardiovascular epigenetics. We welcome insights into epigenetic mechanisms associated with development, physiology, and the pathological process of cardiac disease, involving DNA methylation, post-translational modification of histones, chromatin conformation and remodeling, and non-coding RNAs.

Cardiovascular diseases are the main cause of death, and the most prevalent congenital abnormalities are those of the heart. Cardiac epigenetics studies many processes that regulate gene expression independently of the genetic code. These gene regulation processes are crucial for basic cardiac physiological activities like cell growth, development, and differentiation, but they are also involved in aging and disease. In addition, a growing body of evidence supports the usefulness of epigenetic drugs as novel therapies for the treatment of cardiac disease. Therefore, we consider this article collection to be of critical relevance for the progress of the study of cardiac health, pathology, and development.

This article collection aims to showcase the latest advancements in cardiac epigenetics. We welcome submissions addressing the following themes, among others:

  • Epigenetic processes involved in cardiac pathology, development, or regeneration.
  • Innovative tools enhancing the analysis of heart epigenetics.
  • Systems biology studies elucidating the epigenetic mechanisms underlying heart diseases.
  • Clinical research evaluating the efficacy and safety of epigenetic therapies for heart disease and the emergence of epigenetic biomarkers for early detection and prognosis of heart diseases.
  • The role of environmental and lifestyle factors in shaping cardiac epigenetics and their impact on heart health.
  • Comparative studies exploring epigenetic differences in heart disease across various populations and demographics.

5 Keywords:

  1. Heart Physiology
  2. Cardiac Pathology
  3. Cardiac Development
  4. Chromatin Remodeling
  5. Cardiac Epigenetics

Guest Advisors

Dr. Manuel Rosa-Garrido received his PhD from the University of Cantabria (Spain), where he studied the epigenetic regulation of leukemia. He was then recruited by the University of California, Los Angeles (UCLA), where his postdoctoral work focused on the role of chromatin structure and epigenetics in the development of heart failure. During this period, he was awarded a postdoctoral fellowship from the American Heart Association (AHA), the AHA Outstanding Early Career Investigator Award, and the AHA Career Development Award, which enabled him to become an independent researcher at UCLA. In 2022, Dr. Rosa-Garrido was appointed as a tenure-track Assistant Professor in the Department of Biomedical Engineering at the School of Medicine, University of Alabama at Birmingham. His current work focuses on developing new tools to treat cardiac disease by remodeling chromatin structure. For further details about Dr. Rosa-Garrido's professional profile, kindly refer to these links:,

Dr. Luis Hortells obtained his DVM (Doctor in Veterinary Medicine) University of Zaragoza, Aragon. Then, and for the next 4 years, he worked as an assistant professor in the molecular toxicology department of the University of Zaragoza while he also developed his PhD research.  In 2016, Dr. Hortells obtained his PhD and moved to the US where he developed 4 years of postdoctoral research. During his time in the Heart Institute of the Cincinnati Children’s Hospital he obtained a postdoctoral Scholarship from the American Heart Association and also was awarded with the Arnold Strauss award to perform independent research. Since early 2021 Dr. Hortells moved to Freiburg with the goal of starting his own group focused on the study of the intracardiac nervous system while maintaining a close collaboration with groups from the University of Zaragoza, University of Alabama (Birmingham), Cincinnati Children’s Hospital or University of Colorado (Denver). For further details about Dr. Luis Hortells's professional profile, kindly refer to these links:,

Dr. Marta Szulik received her PhD from Vanderbilt University, where in Dr. Mike Stone’s Lab she studied structural biology of DNA. Then for her academic training, she came to the University of Utah and joined Dr. Buck-Koehntop Lab where she continued structural and biophysical studies of epigenetically modified DNA and the mechanisms of DNA recognition by transcription factors. Subsequently, she joined Dr. Sarah’s Franklin Lab at the Nora Eccles Harrison Cardiovascular Research & Training Institute (CVRTI) at the University of Utah, where she studied epigenetic mechanisms in the development of cardiac hypertrophy and heart failure. During her scientific career, Marta received numerous awards and travel grants, including NIH NRSA F32 Fellowship or postdoctoral fellowship from the American Heart Association (AHA). She was also the Finalist for the Young Investigator Competition Award from the International Society for Heart Research (ISHR). Currently, she is an Associate Instructor at CVRTI where she continues research on cardiac epigenetics, biochemistry, and heart biology for a comprehensive understanding of how chromatin structure contributes to mammalian physiology and human health. For further details about Dr. Szulik's professional profile, kindly refer to these links:,

Disclosure Statement: All guest advisors declare no conflict of interest regarding this work.

All manuscripts submitted to this Article Collection will undergo a full peer-review; the Guest Advisor for this Collection will not be handling the manuscripts (unless they are an Editorial Board member).

Please review the journal scope and author submission instructions prior to submitting a manuscript.

To submit your papers to this Article Collection, please:

  1. Check "yes" for the question, "Are you submitting your paper for a specific special issue or article collection?"
  2. Select the Article Collection Epigenetics: Epigenetics in Cardiovascular Health, Pathology, and Development’  from the drop-down menu under the question, "Special Issue or Article Collection Name."

Please contact Changluan Zhou at [email protected] with any queries and discount codes regarding this Article Collection.


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All manuscripts submitted to this Article Collection will undergo desk assessment and peer-review as part of our standard editorial process. Guest Advisors for this collection will not be involved in peer-reviewing manuscripts unless they are an existing member of the Editorial Board. Please review the journal Aims and Scope and author submission instructions prior to submitting a manuscript.