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Submit a Manuscript to the Journal

Drug Delivery

For an Article Collection on

Advances in Nucleic Acid Delivery Strategies for Cancer Therapy

Manuscript deadline
25 December 2023

Cover image - Drug Delivery

Article collection guest advisor(s)

Dr Carla Lucia Esposito, Institute Experimental Endocrinology and Oncology "Gaetano Salvatore" (IEOS), National Research Council (CNR)
[email protected]

Dr Silvia Catuogno, Institute Experimental Endocrinology and Oncology "Gaetano Salvatore" (IEOS), National Research Council (CNR)
[email protected]

Dr Deborah Rotoli, Institute Experimental Endocrinology and Oncology "Gaetano Salvatore" (IEOS), National Research Council (CNR)
[email protected]

Submit an ArticleVisit JournalArticles

Advances in Nucleic Acid Delivery Strategies for Cancer Therapy

Cancer is a leading cause of death worldwide. Despite advances, standard treatments often show a limited effectiveness associated to low bioavailability and the lack of selectivity for tumour cells. Therefore, the development of new effective and targeted therapeutics is a key challenge. Nucleic acid (NA) therapeutics, including siRNAs, miRNAs/antimiRs, gRNAs and ASO, represent a powerful tool for a precision and personalized therapy of cancer.

However, their efficiency is limited by their intrinsic physicochemical properties including their hydrophobicity and susceptibility to enzymatic digestion, and the lack of tumour specificity. Advances in NA design improving stability have been made. However, their broad clinical applicability requires the development of effective delivery systems able to protect nucleic acid therapeutics and allow their specific release to the diseased tissues, avoiding the action on healthy organs, upon systemic administration. Improvements in NA delivery systems will strongly influence their affirmation as concrete therapeutic options for cancer.

This special issue aims to provide an overview of the latest advances in the strategies for the delivery of nucleic acid-based therapeutics to cancer cells. Reviews and original articles from worldwide experts in the fields of chemistry, biology, biotechnology, and pharmaceutics are welcome.

Subtopics include, but are not limited to:

  • viral and non-viral vectors
  • aptamer-based systems
  • si/miRNA delivery
  • mRNA delivery
  • combined delivery of drugs and nucleic acids
  • nanoparticles-based systems
  • trafficking mechanisms
  • biodistribution
  • efficacy studies in vivo, ex vivo, and in vitro

Benefits of publishing open access within Taylor & Francis

Global marketing and publicity, ensuring your research reaches the people you want it to.

Article Collections bring together the latest research on hot topics from influential researchers across the globe.

Rigorous peer review for every open access article.

Rapid online publication allowing you to share your work quickly.

All manuscripts submitted to this Article Collection will undergo desk assessment and peer-review as part of our standard editorial process. Guest Advisors for this collection will not be involved in peer-reviewing manuscripts unless they are an existing member of the Editorial Board. Please review the journal Aims and Scope and author submission instructions prior to submitting a manuscript.

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