Critical Insights in Biotechnology

Developing Synthetic Biology Tools for Non-Model Organisms

The field of synthetic biology has made remarkable strides using model organisms. These systems have provided robust platforms for developing genetic tools, standardized parts, and engineered pathways. However, the next frontier lies in adapting these tools for non-model organisms. This will create opportunities to utilise organisms that offer unique metabolic capabilities.

We are interested in exploring the development, adaptation, and application of synthetic biology tools in non-model organisms. We aim to showcase the innovations, challenges, and opportunities involved in transferring and optimizing genetic systems beyond traditional hosts.

We accept Original Research, Methods Articles and Insights Articles.

Topics of interest include (but are not limited to):

• Genomic and transcriptomic characterization of non-model organisms
• Genome editing and engineering tools development or adaptation to new hosts
• Engineering regulatory elements for new hosts, (e.g.  promoters, terminators, RBSs etc.)
• Development of transformation and expression systems
• Orthogonal genetic circuits and host-independent modules
• Metabolic engineering in extremophiles, marine microbes, and plant-associated species
• Case studies of successful tool adaptation and bioproduction
• Computational approaches for tool design and host optimization
• High-throughput screening approaches for selecting desirable traits
• Development of molecular delivery mechanisms (e.g., engineered gene drives, viral vectors, nanoparticles) for transformation without conventional culturing
• Automation and robotics in experimental workflows to accelerate development