Therapeutics and Clinical Risk Management

Current and Emerging Strategies in the Management of Cardiac Arrhythmias

Cardiac arrhythmias remain a major cause of morbidity, mortality, hospitalization, and impaired quality of life worldwide. They encompass a broad and increasingly complex spectrum of disorders, ranging from atrial fibrillation and supraventricular tachycardias to ventricular arrhythmias, conduction disease, and inherited arrhythmic syndromes. Over the past few years, the field has evolved rapidly, driven by major advances in catheter ablation technologies, physiological pacing, multimodality imaging, digital diagnostics, and data-enabled clinical decision-making. In particular, pulse field ablation has reshaped the contemporary atrial fibrillation ablation landscape, while conduction system pacing has emerged as a major development in device therapy. At the same time, artificial intelligence, wearable devices, and remote monitoring are redefining how arrhythmias are detected, risk-stratified, and followed longitudinally. This Article Collection will provide a contemporary forum for high-quality work addressing both established and emerging strategies in arrhythmia management across a wide range of clinical settings.

This topic is particularly timely because arrhythmia care is entering a phase of substantial therapeutic and technological transition. Traditional management models based largely on symptom status and broad rhythm categories are increasingly being replaced by more individualized approaches that integrate substrate characterization, disease stage, comorbidity burden, procedural strategy, and continuous rhythm surveillance. New ablation platforms, especially pulse field ablation, have raised important questions regarding comparative efficacy, safety, lesion durability, procedural efficiency, and patient selection. Similarly, the expansion of conduction system pacing is reshaping practice in bradyarrhythmia management and cardiac resynchronization. Meanwhile, digital health tools and AI-enabled analytics are creating new opportunities for earlier diagnosis, outcome prediction, and more precise follow-up, but they also introduce challenges related to validation, implementation, workflow integration, and clinical interpretability. Bringing these developments together in one Collection is important not only for summarizing current evidence, but also for identifying where genuine innovation is improving patient care and where critical knowledge gaps remain.
This Article Collection welcomes submissions spanning the full spectrum of contemporary arrhythmia management. Topics of particular interest include atrial fibrillation screening and prevention; catheter ablation strategies for atrial and ventricular arrhythmias; pulse field ablation and other evolving energy sources; substrate-based ablation and adjunctive lesion-set strategies; conduction system pacing and advances in cardiac implantable electronic devices; sudden cardiac death prevention; management of electrical storm and complex ventricular arrhythmias; inherited arrhythmia syndromes and cardiogenetics; imaging-guided electrophysiology; wearable technologies and remote rhythm monitoring; artificial intelligence and predictive analytics in arrhythmia care; and arrhythmia management in patients with heart failure, diabetes, obesity, chronic kidney disease, and other high-risk comorbid conditions. The Collection would particularly benefit from original clinical studies, translational investigations, state-of-the-art reviews, systematic reviews and meta-analyses, expert perspectives, and clinically focused narrative reviews that bridge mechanistic insight with therapeutic relevance and risk management.

Keywords:

1. Cardiac arrhythmias
2. Atrial fibrillation
3. Catheter ablation
4. Conduction system pacing
5. Digital health and artificial intelligence