Immunotherapy has emerged as a promising treatment strategy for various types of cancer. However, these therapies are limited, in part, by a paucity of antigen targets for immunotherapy. Here, we are assembling a collection of articles on “Identifying Antigen Targets for Immunotherapy” to advance the efficacy and specificity of these therapies.
Cancer cells often evade the immune system by expressing low levels of antigens or by down-regulating their expression. By identifying tumour-specific antigens that are highly expressed on cancer cells, immunotherapies can be designed to specifically target and destroy cancer cells while sparing normal cells. Additionally, understanding the immune response to these antigens can provide insight into the mechanisms of immune escape and inform the development of new immunotherapeutic strategies.
We welcome all submissions of original research articles, reviews, and perspectives related to identification of target antigens for immunotherapy, particularly the following subtopics: discovery and validation of novel antigen targets, characterization of the immune response to antigens, antigenic combinations, and the development and optimization of immunotherapeutic strategies targeting tumour antigens. We encourage submissions from diverse fields including cancer biology, immunology, and translational research.
Dr. Snook is a cancer immunologist in the Departments of Pharmacology, Physiology, & Cancer Biology and Microbiology & Immunology at Thomas Jefferson University where he is developing new cancer immunotherapies. His work has led to investigator-initiated clinical trials examining colorectal cancer chemoprevention, cancer vaccines, and CAR-T cell therapies. He is an Assistant Program Leader of the Immune Cell Regulation and Targeting (IRT) Program of the Sidney Kimmel Cancer Center. He is also Director of the Clinical & Translational Research track of the JeffMD Scholarly Inquiry Program of the Sidney Kimmel Medical College.
You can learn more about Dr. Snook's work by visiting https://research.jefferson.edu/labs/researcher/snook-laboratory.html
