Cancer Biology & Therapy

Cancer Biology & Therapy is pleased to invite you to submit your research to the upcoming Article Collection “Clinicopathologic and Biologic Aspects of Pediatric Tumors” organized by Guest Advisors Professor Atif A. Ahmed and Dr. Terrie Flatt.

Pediatric tumors have unique clinical, pathologic, and genetic features and exhibit a certain genome that is different from adults. The incidence of pediatric tumors varies in different racial and ethnic groups reflecting a biologic, genetic and environmental basis for the ethnic disparity. Although most tumors are benign, cancers can occur leading to considerable mortality and morbidity. Significant morbidity and mortality can also be caused by tumors of intermediate malignancy and benign brain tumors. The classification of pediatric tumors continues to evolve with addition of molecular schemes and other ancillary tests that have resulted in tumor reclassification and incorporation of novel tumor entities. Treatment of pediatric cancer is complex and involves a multidisciplinary team that includes surgeons, oncologists, pathologists and radiologists. Using this approach, localized malignancies can be treated with high success rate. However, management of metastatic tumors is burdened with low survival rates inciting a burgeoning research interest for better treatment outcome.

Research in pediatric tumors is continuously evolving prompting the special emphasis highlighted in this article collection. Such research will pave the way for novel treatment modalities and other targeted therapy. Genetic and epigenetic sequencing studies will open new opportunities for patients to be included in clinical trials. This article collections aims to highlight recent research advances in pediatric tumor biology, including pathology, tumor microenvironment, cellular and genetic landscape, and biologic basis of immunotherapy and other targeted therapy.

In this Article Collection, original research articles, and reviews are welcome that can cover various aspect of pediatric tumor research including cancer predisposition syndromes, animal models of pediatric cancer, pathophysiology of different pediatric tumors, translation research, genetic landscape, prognostic and predictive markers, and biologic basis of cancer treatment.

 

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All manuscripts submitted to this Article Collection will undergo desk assessment and peer-review as part of our standard editorial process. Guest Advisors will not be involved in peer-reviewing manuscripts unless they are an existing member of the Editorial Board.

Please review the journal scope and author submission instructions prior to submitting a manuscript.

The deadline for submitting manuscripts is 30th April 2024.

Please contact Marya Baig at [email protected] with any queries regarding this Article Collection.

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Article Collection Guest Advisor(s)

Professor Atif Ali Ahmed is a senior pediatric pathologist at Seattle Children's Hospital, Seattle, WA, USA. Recently, he was professor of pathology and Division director of Anatomic Pathology at Children’s Mercy Hospital, Kansas City, Missouri. He graduated from medical school in 1988, and completed pathology residency and fellowship training in the U.S.A. and is board-certified in Anatomic, Clinical and Pediatric Pathology. Professor Ahmed has been in academic practice for more than 19 years with clinical and research experience in pediatric pathology. His research interests include pediatric tumors, bone pathology and pediatric cancer biology. Professor Ahmed has over 100 academic publications including peer-reviewed articles, books and meeting abstracts, and is a member of the Society for Pediatric Pathology, Children’s Oncology Group, the American Association for Cancer Research, the American Society of Human Genetics and the College of American Pathologists.

Dr. Terrie Flatt is the Director of the Clinical and Research Program for Hispanic Children with Cancer and Blood disorders, often referred to as the HOPE Clinic (Clínica de Hematología y Oncología: Puente de Esperanza, at Children's Mercy Hospital. He is also an Associate Professor Pediatrics at the University of Missouri in Kansas City. His research interests focus on pediatric cancer outcomes among Hispanic children. The goal of his team is to better understand the biologic and socio-cultural factors that affect cancer outcomes among Hispanic children. They have 3 international current studies that include over 8 hospitals in Mexico and their primary focus is on acute lymphoblastic leukemia and childhood sarcomas. His primary research team includes Dr. Lilia Garcia Rodriguez, MD who oversees all studies in Mexico and Dr. Elizabeth Gonzalez Dominguez, MD/PhD Candidate who is performing bench research at CMH for our sarcoma study. He is committed to global health and educating physicians and PhDs from Mexico and Latin America.

Instructions for Authors