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Biotechnology & Biotechnological Equipment

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Long term effects of COVID-19 (post-COVID conditions)

Manuscript deadline
22 March 2024

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Article collection guest advisor(s)

Prof. Iva Christova, Centre of Infectious and Parasitic Diseases, Sofia, Bulgaria

Prof. Mariyana Stocyheva, Medical University - Plovdiv, Department of Infectious Diseases, Plovdiv, Bulgaria

Assoc. Prof. Ivaylo Alexiev, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria

Prof. Borislav Georgiev, National Heart Hospital, Sofia, Bulgaria

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Long term effects of COVID-19 (post-COVID conditions)

Symptoms of COVID-19 can last weeks, months or even years after the acute stage of the disease. Clinical manifestation can involve every organ and system in the human body. The topic is of growing importance now when COVID-19 is not very severe but a large proportion of human population still suffered from COVID-19 consequences. People at higher risk to develop long-COVID are those who had severe COVID-19, underlying health conditions, not vaccinated, etc. The symptoms of long-COVID may include headache, sleep problems, low concentration (brain fog), chest pain, trouble breathing, cough, fatigue, sometimes resulting in disability.

New technological advancements have developed important tools and methodologies for the diagnosis, treatment, and preventions on long COVID. In this Article Collection we are seeking original research, case reports and reviews on the use of biotechnology in the management of long-COVID. Specific subtopics include:
1. Investigations on various clinical manifestations of long-COVID, such as respiratory symptoms, heart symptoms, neurologic symptoms, digestive symptoms, etc., using biotechnological tools for diagnosis (real-time PCR, RT-LAMP, full genome sequencing, micro-array tests; biomarkers, biosensors, nanotechnology).
2. Molecular epidemiology of current SARS-CoV-2 variants; distribution, dominance, evolution of SARS-CoV-2 variants of interest and their subvariants.
3. Recent biotechnological approaches for treatment of COVID-19 based on neutralizing monoclonal antibodies and antiviral drugs.
4. Prevention of COVID-19 by monovalent or bivalent vaccines, vaccine effectiveness, safety, vaccination.


Iva Christova, MD is a Professor, Director of National Centre of Infectious and Parasitic Diseases, Sofia, Bulgaria. She is a specialist in microbiology, virology, immunology and epidemiology with main research interest in vector-borne infectious diseases and viral hemorrhagic fevers, especially in their diagnostics, pathogenesis and epidemiological aspects.

Mariyana Stoycheva, MD is a Professor, Head of Department of Infectious Diseases, Parasitology and Tropical Medicine at University Hospital “St. George”. She is a PhD and Doctor of Sciences; specialist in infectious diseases with main research interest in HIV/AIDS, infections of central nervous system and intestinal infections with diarrheal syndrome.

Ivaylo Alexiev is Associated Professor at National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria and Head of National reference confirmatory laboratory of HIV, PhD, specialist in clinical virology, molecular biology (RT-PCR, Real-Time PCR, sequencing and analysis, quantitative PCR, bDNA hybridisation, HLA typing) and bioinformatics (phylogenetic analysis programs – MEGA, Bioedit, FastTree).

Borislav Georgiev, MD, PhD is Professor of cardiology, Head of Clinic of Cardiology at the National Heart Hospital, Sofia, Bulgaria. He is a specialist in internal medicine and cardiology. Areas of scientific interests – prevention of cardiovascular diseases, arterial hypertension, dyslipidemia, familial hypercholesterolemia, cardiovascular pharmacotherapy, rhythm disorders, pulmonary arterial hypertension. Proficient in noninvasive cardiovascular diagnostics, special interest in 24-hour blood pressure monitoring.

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All manuscripts submitted to this Article Collection will undergo desk assessment and peer-review as part of our standard editorial process. Guest Advisors for this collection will not be involved in peer-reviewing manuscripts unless they are an existing member of the Editorial Board. Please review the journal Aims and Scope and author submission instructions prior to submitting a manuscript.