Multicellular organisms are a complex tapestry where cellular fate and adaptability are shaped by epigenomic programming and intricate interactions, reflecting both external and internal cues. This adaptability, while offering potential advantages, presents challenges in maintaining cellular fidelity and balancing cell death with pro-survival mechanisms, emphasizing the importance of understanding cellular evolution for therapeutic advancements. Advanced systems biology approaches, using relevant physiological models, are pivotal in unravelling this intricate cellular interplay.
This Article collection aims to present research articles, and reviews that delve into the intricate world of molecular, cell, and systems biology. The focus is on the holistic approach that integrates single-cell sequencing, long-read sequencing techniques, advanced micro-physiological systems, and cutting-edge imaging.
Topics of interest will encompass:
1. Cellular Fate, Death Mechanisms, and Therapeutic Implications:
The collection will delve into the diverse cell death mechanisms, particularly in the context of development and oncogenesis. Central to this exploration will be the intricate balance between cell metabolic control, autophagy-apoptosis dynamics, and other programmed cell death pathways. The potential and challenges of therapeutically manipulating these mechanisms will be highlighted, underscoring the significance of understanding cellular evolution for medical advancements.
Furthermore, the collection invites contributions that investigate the myriad cellular processes, such as autophagy, cellular recycling, cell migration, metastasis, cellular senescence, aging, mitochondrial cellular heterogeneity, perturbation, organelle interactions, and more. These processes play pivotal roles in modulating cell fate in both health and disease. We particularly welcome papers that present novel therapeutic approaches to manipulate and harness these processes for improved health outcomes.
Dr. Soren Hayrabedyan earned his PhD in Immunology from the Institute of Biology and Immunology of Reproduction (IBIR), BAS, Sofia, and underwent postdoctoral training at Massachusetts General Hospital/Harvard Cutaneous Biology Research Center. As the Director at IBIR and Full Professor in Immunology, he's led pioneering research in reproductive immunology on Sertoli inflammasome signalling. His contributions have earned him nominations for awards like "Pythagoras" and memberships in esteemed societies like ESRI, ASRI and ISIR. Additionally, he's been honoured to serve as the President of the International Coordination Committee for Immunology of Reproduction since 2018. Dr. Hayrabedyan has enriched the scientific community with his involvement in 3 scientific books, one monography, and 62 peer-reviewed research papers, which have been cited over 1372 times.
His research interests lie in the intersections of reproductive and cancer immunology, particularly focusing on innate immunity signalling and inflammasome dynamics, enhanced by his exploration in multi-dimensional data analysis, imaging, and nanopore sequencing. He is currently actively contributing (Consortium Partner Coordinator) for the establishment of RI (InfraACT) dedicated on translational research using multi-OMICs analyses and multi-modal imaging of additive human tissue biomodels.
Associate Professor Milena Mourdjeva is a leading scientist in the field of stem cells in Bulgaria. She has extensive experience in studying mesenchymal stem cells (MSC) and their role in various cellular and biological processes. She is the author of over 40 publications in prestigious scientific journals, which have been cited over 500 times. Her research group has focused on studying the role of MSC in inflammation and regeneration of bones and joint surfaces. They have discovered that MSC can play a key role in regulating inflammation and regeneration of bones and joints. These discoveries have the potential to lead to new treatments for inflammatory diseases of the bones and joints, such as osteoarthritis.
Associate Professor Milena Mourdjeva is an active lecturer and supervisor of PhD students. She is a lecturer at the Department of Biology at Sofia University "St. Kliment Ohridski" and at the Institute of Biology and Immunology of Reproduction. She is also the leader of several national and European projects.
Milena Mourdjeva (0000-0003-1416-1457) - ORCID
