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Submit a Manuscript to the Journal

Annals of Medicine

For an Article Collection on

Mutation-Independent Factors for Carcinogenesis and Cancer Progression: From Bench to Bedside

Manuscript deadline
31 March 2023

Cover image - Annals of Medicine

Article collection guest advisor(s)

Hao Zhang, Institute of Cancer Precision Medicine, Medical College of Jinan University, Guangzhou, China
[email protected]

Sai-Ching Jim Yeung, University of Texas MD Anderson Cancer Center, Houston, Texas, United States
[email protected]

Rakesh Kumar, Cancer Research Institute, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, India
[email protected]

Submit an ArticleVisit JournalArticles

Mutation-Independent Factors for Carcinogenesis and Cancer Progression: From Bench to Bedside

Although it is widely accepted that genetic mutations play pivotal roles in tumor initiation, cancer progression, and recurrence, cancers solely caused by genetic mutations are relatively rare. Currently, therapeutic targets of most approved cancer drugs are based on somatically mutated oncogenes, and detection of somatic mutations of candidate genes is of high significance for clinicians and translational cancer biologists. However, mutation-based targets and relevant indicators are rare or even non-existing in the majority of malignancies.

Accumulating evidence indicates that somatic mutations can exist in the normal tissues without leading to cancer. Phenotypically normal cells carrying somatic mutations appear to colonize in human tissues such as the esophagus during aging. Cells with cancer-associated mutations cover much of the epithelium in middle-aged and elderly subjects. For example, the prevalence of NOTCH1 mutations in the phenotypically normal esophagus is several times higher than that of esophageal cancer.

On the other hand, growing numbers of intrinsic and extrinsic factors, rather than mutations, reportedly affect cancer development and cell plasticity. Therefore, the growing repertoire of mutation-independent factors could become applicable therapeutic targets in cancer treatment.

The objective of this Article Collection is to publish original research papers, reviews, and comments from authors who are interested in addressing these challenges and providing new insights into the mutation-independent driving force for cancer progression, or tumor evolution, relevant clinical translational evidence, or hypotheses in harnessing these non-genetic (mutation-independent) alterations in cancer theragnostics.

We aim to solicit papers on, but not limited to, the following topics:

- Genomic and non-genomic dysregulation in cancer progression
- Targeted cancer therapeutics and molecular indicators
- Mutation-independent cancer drivers and targets
- Cell-state heterogeneity in cancer cells and microenvironment
- Proof-of-principle cancer clinical trials

Annals of Medicine accepts the following types of articles:

  • Research Article
  • Clinical Study
  • Study Characteristics
  • Systematic Review
  • Review Article
  • Mini Review
  • Case Series

When submitting your article, please select the section, 'Oncology', and the Special Issue, 'Mutation-Independent Factors for Carcinogenesis and Cancer Progression: From Bench to Bedside' from the drop-down menu on the submission system.

Benefits of publishing open access within Taylor & Francis

Global marketing and publicity, ensuring your research reaches the people you want it to.

Article Collections bring together the latest research on hot topics from influential researchers across the globe.

Rigorous peer review for every open access article.

Rapid online publication allowing you to share your work quickly.

All manuscripts submitted to this Article Collection will undergo desk assessment and peer-review as part of our standard editorial process. Guest Advisors for this collection will not be involved in peer-reviewing manuscripts unless they are an existing member of the Editorial Board. Please review the journal Aims and Scope and author submission instructions prior to submitting a manuscript.

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