Microglia, the resident immune cells of the central nervous system, have been recognized as culprits of neuroinflammation in neurodegenerative diseases. These cells can produce reactive oxygen species and inflammatory factors that induce neurotoxicity and neuronal apoptosis, making them important effectors in these diseases. Microglia have emerged as an essential component in innate immunity and play a vital role in central nervous system development, health, response to injuries, and neurodegenerative diseases. They have immense phenotypic diversity which relies on intrinsic and extrinsic factors. The transcriptional profiles and motility of microglia, the effects of aging, stress, and other microenvironmental stimuli are different in various brain regions. Morphology, phenotypes, functions, and signaling pathways are diverse among microglia.
Understanding the role of microglia and their correlation with the central nervous system provides therapeutic strategies to avoid that impaired microglia contribute to neuroinflammation and neurodegeneration, identifying drivers of research and progress, and analyzing potential solutions to challenges for the researchers.
For this Article Collection, the goal is to solicit submissions of any articles that provide important insights into the field of microglia and their role in neuroinflammation, neurocognitive functions, and neurodegenerative diseases, from the aspects of mechanisms, development, pathogenesis, diagnosis, and therapeutics, including but not limited to the subtopics highlighted below:
- Studies of the molecular factors and mechanisms of microglia
- Studies on the relationship between the role of microglia in the central nervous system and immune system
- Studies to understand the role of microglia in the central nervous system, including neuroinflammation, neurocognitive functions, and neurodegeneration
- Studies of the pathogenetic role of microglia in neurocognitive disorders and neurodegenerative diseases
- Studies of identification of new microglial biomarkers and related diagnosis
- Studies of potential microglial therapeutic targets and related treatment
Annals of Medicine accepts the following types of articles:
- Research Articles
- Review Articles
- Clinical Trials
- Protocols
- Case Series
- Commentaries
- Letter To The Editor
When submitting your article, please select the section, ‘Neurology’, and the Article Collection, ‘Microglia in Neuroinflammation, Neurocognition, and Neurodegenerative Diseases’ from the drop-down menu on the submission system.
Please feel free to contact Sam Zhang (sam.zh[email protected]) for more information and the discount.
Annals of Medicine is an online, open access, international journal publishing across all areas of medicine and is part of our Elevate Series. This means that you will receive a concierge-level publishing experience, including dedicated support from our expert in-house Editorial team, with guaranteed response times of within 48 hours, an initial decision on whether your article will be peer reviewed within 5 working days, and a first decision on your research within an average of 22 working days.
