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Submit a Manuscript to the Journal

All Life

For an Article Collection on

The Role of Gender and Sex in Pharmacology

Manuscript deadline
31 March 2023

Cover image - All Life

Article collection guest advisor(s)

Dr. Stefania Nobili, “G. d’Annunzio” University of Chieti-Pescara, Department of Neuroscience, Imaging and Clinical Sciences, via L. Polacchi 11, 66100 Chieti, Italy

Dr. Antonella Mannini, University of Florence, Department of Experimental and Clinical Medicine, Viale G.B. Morgagni 50, 50134 Firenze, Italy

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The Role of Gender and Sex in Pharmacology

It is widely recognized that drug response, in terms of efficacy and toxicity, depends on several determinants including a number of host-related factors. Among these factors, mainly represented by age, genetics, organ function, concomitant medications, sex is also included. From a terminological point of view, the term “sex” is associated with biological functions whereas the term “gender” is mainly associated with culture, environment and social aspects. However, these terms, although separate, are highly intertwined.

From a historical point of view, the first evidence of a difference between sexes in pharmacology was in 1932 when Nicholas and Barron showed the marked differences in a safe dose of hexobarbital between female and male rats. Today, most of the available knowledge on sex differences in pharmacology concerns pharmacokinetic data and, to a lesser extent, pharmacodynamic data with a major impact on toxicity than on efficacy.

However, 90 years on from the findings of Nicholas and Barron, and despite the attention that international drug agencies (e.g. FDA, EMA) as well as international research programs promoted by the most important organizations (e.g. H2020 EU programs and beyond) are dedicating to this issue, the concept that sex may affect drug response is still not supported by adequate sex/gender-oriented research. Thus, current clinical practice does not consider sex/gender difference in the administration of drugs.

The aim of this Article Collection is to collect original papers and reviews on the topic of sex/gender-oriented pharmacological research able to contribute to the improvement of the current knowledge on this topic.

All the areas of pharmacology may be covered through the most innovative approaches at preclinical, translational or clinical level.

Some examples (but not limited to) of specific pharmacological areas that can be covered are:

  • Cardiovascular pharmacology
  • Neuropharmacology
  • Pharmacology of anticancer drugs
  • Pharmacology of infectious diseases
  • Pharmacology of inflammation

Pharmacokinetic, pharmacodynamic, pharmacogenetic and pharmacogenomic studies on such pharmacological areas are welcome.

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All manuscripts submitted to this Article Collection will undergo desk assessment and peer-review as part of our standard editorial process. Guest Advisors for this collection will not be involved in peer-reviewing manuscripts unless they are an existing member of the Editorial Board. Please review the journal Aims and Scope and author submission instructions prior to submitting a manuscript.

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