Clinical Management of Pediatric Leukemias: From Diagnosis Through Long-Term Survivorship

Pediatric leukemias account for one-third of childhood cancers, with cure rates now exceeding 90% for acute lymphoblastic leukemia (ALL) and approaching 70% for acute myeloid leukemia (AML). These remarkable outcomes reflect decades of advances in risk stratification, treatment protocols, and supportive care. However, optimal management requires sophisticated clinical approaches spanning initial diagnosis through lifelong survivorship.

This comprehensive Article Collection provides evidence-based guidance for managing pediatric leukemias across the complete disease trajectory. Expert contributors address critical aspects including modern diagnostic evaluation using molecular profiling and cytogenetics, risk-adapted treatment strategies tailored to disease biology and treatment response, contemporary chemotherapy protocols for ALL, AML, and rare leukemia subtypes, emerging targeted therapies and immunotherapies including CAR T-cell therapy, hematopoietic stem cell transplantation indications and management, minimal residual disease monitoring for treatment adaptation, management of relapsed and refractory disease, and comprehensive survivorship care addressing late effects and quality of life.

The Collection emphasizes precision medicine approaches that match therapies to specific genetic alterations while balancing cure with minimizing long-term toxicity. Special attention is given to managing treatment complications, supporting patients and families through the psychosocial challenges of cancer treatment, and ensuring appropriate transition to adult-focused survivorship care.

The benefit of publishing as part of an Article Collection is that they often become a key resource, driving a research community forward. This has a synergistic effect on every article in the Collection. The articles often receive more views and higher citation numbers as the Collections receive increased promotion via social media and our marketing team.

If you are interested in contributing, or would like to learn more, then please reach out to the Commissioning Editor, Lucy Anderson, who will be happy to assist.