Platelets

Platelets, Ageing, and Disease

Platelets form a heterogenous population of sizes and functions, the balance of which is important for maintaining haemostasis. Recent work has shown that a key influence in these differences may be platelet age. In this regard, platelet ageing can be defined in two ways, firstly the age of the circulating platelet following its release from the parent megakaryocyte, or alternatively, the function of platelets in aged people. Both definitions are important for our understanding of platelet physiology and platelet contribution to pathology.

There are associations between platelet age and disease. The breadth of research being performed in this area is large, however the nomenclature to define parameters associated with platelet age are varying including, young/old, immature/mature, reticulated/non-reticulated. This collection will allow us to understand the important factors governing platelet ageing and the functions of platelets in people as they age, and their contributions to changes in platelet function in disease.

This collection will highlight the importance of circulating platelet age in health and disease, as well as platelet function in ageing people. Subtopics will cover:

• Platelet function in aged populations
• Platelet ageing in the physiological circulation.

Platelet ageing in pathological conditions including cardiovascular disease, inflammation, diabetes mellitus and cancer.

­­All manuscripts submitted to this Article Collection will undergo a full peer-review; the Guest Advisor for this Collection will not be handling the manuscripts (unless they are an Editorial Board member).

Please review the journal scope and author submission instructions prior to submitting a manuscript. Please be sure to select the appropriate Article Collection from the drop-down menu in the submission system.

For more information about discounts or other questions, please contact Commissioning Editor Cassie Houtz at cassie.houtz@taylorandfrancis.com