Redox Report

Redox Response Dynamics in Alzheimer’s Disease: From Pathogenesis to Therapy

Alzheimer’s disease is a debilitating neurodegenerative disorder and a major contributor to dementia in epidemiological terms worldwide. Progressive cognitive deterioration, memory loss and neuron degeneration are the hallmarks of it. Oxidative stress is considered the central player in the pathogenesis of Alzheimer’s disease pathology. An imbalance between the production of reactive oxygen species combined with the brain's limited antioxidant defenses enhance oxidative stress in brain tissues. This imbalance triggers a cascade of molecular events, including lipid peroxidation, protein oxidation, and DNA damage, all contributing to neuronal dysfunction. Understanding how oxidative stress influences Alzheimer’s disease progression is essential for developing novel diagnostic and therapeutic strategies that target specific reactive species.

Oxidative stress is among the most important early events in Alzheimer’s disease, often appearing before amyloid-beta plaques and tau tangles. Because of its high metabolic rate and lipid-enriched environment, the brain is an extremely vulnerable target for reactive oxygen species insult. Detecting oxidative biomarkers in the early phases could give early diagnosis and targeting oxidative pathways has the potential to represent a new avenue for the development of treatments that could suppress or halt disease progression. Although antioxidant therapies have not shown significant clinical efficacy in the treatment of Alzheimer's disease, oxidative stress remains a highly relevant target for future studies due to its central role in the disease's pathophysiology, and its elucidation is essential to obtaining efficacious interventions in Alzheimer’s disease.

This Article Collection will explore the multifaceted role of oxidative stress in Alzheimer’s disease, focusing on redox signaling mechanisms and their implications for disease onset and progression. It aims to highlight insights gained through omics approaches, as well as findings from cellular and animal models. Other subthemes will cover such topics as redox signaling pathways, mitochondrial dysfunction, lipid peroxidation, and oxidative modifications of proteins and nucleic acids. We encourage submissions that investigate to redox biomarkers, antioxidant therapies. Additional themes include the influence of environmental and metabolic factors, epigenetic regulation, gut-brain axis interactions, and sex-related differences in redox responses. We welcome original research articles, reviews, and perspectives that provide new insights into redox system and its relevance to Alzheimer’s disease.

Topics of Interest:

• Antioxidant therapies in Alzheimer’s disease;
• Redox biomarkers in Alzheimer’s disease: advances and challenges;
• Lipid-driven redox responses in Alzheimer’s disease;
• Omics approaches in Alzheimer’s disease studies;
• Animal and cellular models to study redox dynamics in Alzheimer’s disease;
• Environmental and metabolic factors affecting oxidative balance in the brain and their role in Alzheimer’s disease;
• Epigenetic regulation of redox pathways in Alzheimer’s disease;
• Impact of oxidative stress on synaptic dysfunction and neuronal loss in Alzheimer’s disease;
• Mitochondrial dysfunction as a driver of oxidative imbalance in Alzheimer’s disease;
• Role of the gut-brain axis and oxidative stress in Alzheimer’s disease;
• Gender differences in oxidative stress responses in Alzheimer’s disease.

5 Keywords:

1. Alzheimer’s Disease
2. Antioxidant Therapy
3. Omics Technologies
4. Redox Signaling
5. Biomarkers

Guest Advisors:

Dr. Mikaela Peglow Pinz holds a degree in Pharmacy from the Federal University of Pelotas (2016) and obtained both MSc (2018) and PhD (2021) degrees in Sciences, with a specialization in Biochemistry and Bioprospecting. Her academic work has focused on the pharmacological evaluation of selenium-based organic compounds, particularly their antioxidant properties in experimental models of Alzheimer’s disease. Currently, she is a postdoctoral researcher at the Department of Biochemistry, Institute of Chemistry, University of São Paulo, where she investigates the role of organic peroxides in redox signaling using advanced biosensor technologies in mammalian cells. She is also a member of the editorial board of the journal Redox Report. For further details about Dr. Pinz's professional profile, kindly refer to these links: http://lattes.cnpq.br/5409361390945855, https://orcid.org/0000-0003-1153-4916.

Dr. Renata Leivas de Oliveira holds a degree in Pharmacy from the Federal University of Pelotas (2017) and obtained both MSc (2019) and PhD (2023) degrees in Sciences, with a specialization in Biochemistry and Bioprospecting. During her postgraduate studies, she investigated the pharmacological potential of selenium-based organic compounds in different animal models through preclinical studies, with an emphasis on the search for the treatment of depression and Alzheimer's disease. Currently, she is a postdoctoral researcher in the Neurobiotechnology Research Group at the Federal University of Pelotas, where she investigates the gut-brain axis in preclinical models of neuropsychiatric disorders and their comorbidities. For further details about Dr. de Oliveira's professional profile, kindly refer to these links: http://lattes.cnpq.br/1898414452881911, https://orcid.org/0000-0002-9362-8440.

Dr. Karline da Costa Rodrigues graduated in Pharmacy from the Federal University of Pelotas (UFPel-2018), with experience in scientific initiation during graduation (2015-2018). She obtained a MSc degree (2018-2020) and a PhD degree (2020-2024) from the Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio) at UFPel. From April 2023 to March 2024, she carried out a sandwich doctorate at the University of Coimbra (UC), Portugal, in the laboratory "MitoXT - Mitochondrial Toxicology and Experimental Therapeutics". Throughout her academic career, she acquired extensive experience in experimental models with rats and mice, investigation of neurodegenerative and neuropsychiatric diseases, manipulation and differentiation of tissues, as well as work with cell cultures. For further details about Dr. Rodrigues' professional profile, kindly refer to these links: http://lattes.cnpq.br/3934644844193604, https://orcid.org/0000-0003-2495-2252.

Disclosure Statement: Guest Advisors have no conflicts of interest to disclose.

Please review the journal scope and author submission instructions prior to submitting a manuscript.

To submit your papers to this Article Collection, please:

1. Check "yes" for the question, "Are you submitting your paper for a specific special issue or article collection?"
2. Select the Article Collection "Redox Response Dynamics in Alzheimer’s Disease: From Pathogenesis to Therapy" from the drop-down menu under the question, "Special Issue or Article Collection Name."

Please contact Changluan Zhou at [email protected] with any queries and discount codes regarding this Article Collection.