Molecular and Cellular Biology

Multifaceted interaction between metabolism and inflammation in cellular homeostasis

Metabolism and inflammation maintain cellular homeostasis through coordinated crosstalk. Cellular metabolism generates energy substrates like glucose, fatty acids, and proteins - essential building blocks of cells; while inflammation serves as a defense mechanism against cellular stress. Inflammatory mediators can impact metabolic homeostasis and vice versa, thereby creating a self-reinforcing feedforward loop. The convergence of metabolism and inflammation has been implicated under various physiological and pathological conditions, including cancer, metabolic disorders, autoimmune diseases, and neurodegenerative diseases. It is the intricate interplay between cellular signaling, redox regulation, chromatin remodeling, and epigenetics that connects metabolic and inflammatory pathways.

Aberrant metabolism and inflammation are key contributors to metabolic disorders, including cancers, making them critical targets for therapeutic intervention. Investigating the underlying signaling and epigenetic mechanisms linking these processes could reveal novel mediators that govern metabolism-inflammation crosstalk. These mediators will not only illuminate fundamental biological processes but also offer promising therapeutic targets for conditions driven by disrupted metabolic and inflammatory pathways. This could pave the way for innovative strategies to address disorders characterized by aberrant metabolism-inflammation dynamics, ultimately advancing treatment options.

With growing interest in understanding how signaling and epigenetic mechanisms govern the interplay between metabolism and inflammation, this Article Collection addresses key topics to bridge knowledge gaps. These include:

1. Signaling mediators of metabolic reprogramming in inflammation
2. Fatty acid metabolism in inflammatory signaling
3. Convergence of metabolism and inflammation on chromatin architecture
4. Epigenetic memory in inflammatory and metabolic reprogramming
5. Redox Signaling in metabolic-inflammatory cross-talk
6. Therapeutic approaches targeting metabolism-inflammation interface
7. Epigenetic landscape and metabolites in cancer, infection, gut microbiome dysbiosis, and developmental disorders.

5 Keywords:

1. Metabolism
2. Inflammation
3. Epigenetics
4. Gene regulation
5. Chromatin
6. Redox pathway

Guest Advisor

Ellora Sen, Ph. D., currently serves as a Professor at the National Brain Research Centre, India. Her group investigates how distinct metabolic-epigenetic landscape in brain tumors, harboring molecular signatures with prognostic values, influence chemoresistance. Dr. Sen serves on the editorial boards of Cytokine and Journal of Interferon and Cytokine Research. She earned her Ph.D degree from the Indian Institute of Chemical Biology (IICB) in India, and carried out her postdoctoral research at the Pennsylvania State University and Rutgers University in USA. For further details about Prof. Sen's professional profile, kindly refer to these links: https://www.nbrc.ac.in/newweb/, https://www.nbrc.ac.in/newweb/research/groups/ellora-sen, and https://orcid.org/0000-0001-6842-7850.

Disclosure Statement: Prof. Sen has no conflicts of interest to disclose.

Please review the journal scope and author submission instructions prior to submitting a manuscript.

To submit your papers to this Article Collection, please:

1. Check "yes" for the question, "Are you submitting your paper for a specific special issue or article collection?"
2. Select the Article Collection "Multifaceted interaction between metabolism and inflammation in cellular homeostasis" from the drop-down menu under the question, "Special Issue or Article Collection Name."

Please contact Changluan Zhou at changluan.zhou@taylorandfrancis.com with any queries and discount codes regarding this Article Collection.